- South East Dublin Department of Anaesthesia

Clinical Research


Professor Alistair Nichol

Critical Care Medicine

There is an active research programs within the Department of Critical Care Medicine in SVUH.


Clinical research activity includes collaboration with the Australian and New Zealand Intensive Care Research Centre (ANZIC), an internationally renowned research institute lead by Prof Jamie Cooper and Prof Rinaldo Bellomo. We are also involved with the ESICM Trials Group. 

St Vincent’s University Hospital Intensive Care Unit is currently enrolling patients for a number of clinical research studies;.

HARP 2            (Hydroxymethylglutaryl-CoA Reductase Inhibition with Simvastatin in Acute Lung Injury to Reduce Pulmonary Dysfunction) . A phase II randomised controlled trial of simvastatin in patient with Acute Lung Injury.  Lead Prof Danny Mac Auley (Belfast).


ARISE               Australasian Resuscitation In Sepsis Evaluation Randomised Controlled Trial. A  Multi-centre, randomised controlled trial of early goal-directed therapy in patients presenting to the Emergency Department with severe sepsis. Lead Prof Sany Peake (SA, Australia).


TRANSFUSE      STandaRd Issue TrANsfusion versuS Fresher red blood cell Use in intenSive care

                              (TRANSFUSE) – a randomized controlled trial. Lead Prof Jamie Cooper (Vic,     



PHARLAP         A multi-centre randomised controlled trial of an Open Lung Strategy including Permissive Hypercapnia, Alveolar Recruitment and Low Airway Pressure in patients with acute respiratory distress syndrome. A Multi-centre, phase II randomised controlled trial of an open lung ventilation strategy in patients with acute respiratory distress syndrome. Lead Prof A Nichol (Dublin).


AKI                   Prospective Validation of Acute Kidney Injury Biomarkers and Definitions in Critically ill Patients. This observational study is led by Prof P Murray (Dublin).


IC-GLOSSARI  The Intensive Care GLObal Study on Severe Acute Respiratory Infection


Lung – safe

The Intensive Care GLObal Study on Severe Acute Respiratory Infection


We have agreed to join the European CLIN-Net hospital network to participate in the Hospital- and Laboratory Networks CLIN-Net and LAB-Net supporting the consortia COMBACTE, Academic Partners of COMBACTE (APC) Consortium for surveillance, prevention and treatment of hospital-acquired S. aureus infections, and Academic Partners of COMBACTE 2 (APC2).



St Vincent's University Hospital ICU Study updates - November 2016

Kathy our research coordinator in the unit has been fantastic. Today (at 01:30), St Vincent's recruited its 100th patient into TRANSFUSE.  This is a large multi-center RCT, which will address the question of whether fresher blood improves survival compared to standard issue (old) blood. It is a really important and topical issue (for more info see and


We have recruited 33 patients into SPICE: A large phase III RCT, which will determine if sedation with dexmetatomidine impacts survival, length of stay etc.  Like transfuse this is very topical and will have a direct impact on clinical practice and costs (for more info see


PHARLAP: We have recruited 6 patients in St Vincent's University Hospital.  This is a multi center RCT phase II looking at the benefit of an open lung strategy in ARDS.  (for more info see


PEPTIC:  This really novel registry based cluster RCT started in St Vincent's University Hospital last month.  For the next 6 months PPIs will be our default gastric ulcer prophylaxis and after 6 month we will change to H2RB's.  To date we are the only Northern hemispheres ICU to be taking part in this study.


STARRT-AKI:  This study is in collaboration with the Canadian Clinical Trials groups and will look at standard versus accelerated CRRT in AKI in ICU.  We have all the approvals and will start next week.


STOP-AKI: A study looking at alkaline phosphate as a treatment in ICU patients with early AKI.  This is an industry study with Pat Murray (Dean of Medicine in UCD) is a PI and which will start in 3 weeks.


NAPRESSIM: This study lead by Dave C and Niamh and John B has progressed really well under Dave's leadership and has recruited over 20 patients.  This is the first investigator lead Clinical trial (as per the EU directive) that we are aware ahs ever been carried out in Ireland.  The UCD-CRC (P Doran) has been very helpful.


New Projects 2016

A GLP-1 study in post op critically ill patients led by Dr. Shrijitnair SpR will start in end November 2016 in the ICU



Contact Details

Professorial Chair:      Prof A Nichol


Research Coordinator: Edel Meaney