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Publications

SVUH, Department of Anaesthesia, Intensive Care, and Pain Medicine

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2022

Respiratory Support in the Time of COVID-19 Nichol AD, O'Kane C, McAuley DF. JAMA. 2022 Sep 27;328(12):1203-1205. doi: 10.1001/jama.2022.15229. PMID: 36166049.

Galectin-3 Inhibition in COVID-19 Reddy K, Nichol A, McAuley DF. Am J Respir Crit Care Med. 2022 Sep 26. doi: 10.1164/rccm.202209-1758ED. Epub ahead of print. PMID: 36154818.

Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study. Reyes LF, Murthy S, Garcia-Gallo E, Merson L, Ibáñez-Prada ED, Rello J, Fuentes YV, Martin-Loeches I, Bozza F, Duque S, Taccone FS, Fowler RA, Kartsonaki C, Gonçalves BP, Citarella BW, Aryal D, Burhan E, Cummings MJ, Delmas C, Diaz R, Figueiredo-Mello C, Hashmi M, Panda PK, Jiménez MP, Rincon DFB, Thomson D, Nichol A, Marshall JC, Olliaro PL; ISARIC Characterization Group. Crit Care. 2022 Sep 13;26(1):276. doi: 10.1186/s13054-022-04155-1. PMID: 36100904; PMCID: PMC9469080.

A Bayesian reanalysis of the Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial. Zampieri FG, da Costa BR, Vaara ST, Lamontagne F, Rochwerg B, Nichol AD, McGuinness S, McAuley DF, Ostermann M, Wald R, Bagshaw SM; STARRT-AKI Investigators. Crit Care. 2022 Aug 25;26(1):255. doi: 10.1186/s13054-022-04120-y. PMID: 36008827; PMCID: PMC9404618.

Trial Forge Guidance 3: randomised trials and how to recruit and retain individuals from ethnic minority groups-practical guidance to support better practice. Dawson S, Banister K, Biggs K, Cotton S, Devane D, Gardner H, Gillies K, Gopalakrishnan G, Isaacs T, Khunti K, Nichol A, Parker A, Russell AM, Shepherd V, Shiely F, Shorter G, Starling B, Williams H, Willis A, Witham MD, Treweek S. Trials. 2022 Aug 17;23(1):672. doi: 10.1186/s13063-022-06553-w. Erratum in: Trials. 2022 Sep 7;23(1):760. PMID: 35978338; PMCID: PMC9383663.

Co-infection and ICU-acquired infection in COIVD-19 ICU patients: a secondary analysis of the UNITE-COVID data set. Conway Morris A, Kohler K, De Corte T, Ercole A, De Grooth HJ, Elbers PWG, Povoa P, Morais R, Koulenti D, Jog S, Nielsen N, Jubb A, Cecconi M, De Waele J; ESICM UNITE COVID investigators. Crit Care. 2022 Aug 3;26(1):236. doi: 10.1186/s13054-022-04108-8. Erratum in: Crit Care. 2022 Aug 17;26(1):249. PMID: 35922860; PMCID: PMC9347163.

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19. ISARIC Clinical Characterization Group, Garcia-Gallo E, Merson L, Kennon K, Kelly S, Citarella BW, Fryer DV, Shrapnel S, Lee J, Duque S, Fuentes YV, Balan V, Smith S, Wei J, Gonçalves BP, Russell CD, Sigfrid L, Dagens A, Olliaro PL, Baruch J, Kartsonaki C, Dunning J, Rojek A, Rashan A, Beane A, Murthy S, Reyes LF. Sci Data. 2022 Jul 30;9(1):454. doi: 10.1038/s41597-022-01534-9. PMID: 35908040; PMCID: PMC9339000.

Ventilatory settings in the initial 72 h and their association with outcome in out-of-hospital cardiac arrest patients: a preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial. Robba C, Badenes R, Battaglini D, Ball L, Brunetti I, Jakobsen JC, Lilja G, Friberg H, Wendel-Garcia PD, Young PJ, Eastwood G, Chew MS, Unden J, Thomas M, Joannidis M, Nichol A, Lundin A, Hollenberg J, Hammond N, Saxena M, Annborn M, Solar M, Taccone FS, Dankiewicz J, Nielsen N, Pelosi P; TTM2 Trial Collaborators. Intensive Care Med. 2022 Aug;48(8):1024-1038. doi: 10.1007/s00134-022-06756-4. Epub 2022 Jul 2. PMID: 35780195; PMCID: PMC9304050.

Prophylaxis in healthcare workers during a pandemic: a model for a multi-centre international randomised controlled trial using Bayesian analyses. Bruce P, Ainscough K, Hatter L, Braithwaite I, Berry LR, Fitzgerald M, Hills T, Brickell K, Cosgrave D, Semprini A, Morpeth S, Berry S, Doran P, Young P, Beasley R, Nichol A. Trials. 2022 Jun 27;23(1):534. doi: 10.1186/s13063-022-06402-w. Erratum in: Trials. 2022 Jul 5;23(1):546. PMID: 35761370; PMCID: PMC9235209.

People in intensive care with COVID-19: demographic and clinical features during the first, second, and third pandemic waves in Australia. Begum H, Neto AS, Alliegro P, Broadley T, Trapani T, Campbell LT, Cheng AC, Cheung W, Cooper DJ, Erickson SJ, French CJ, Litton E, McAllister R, Nichol A, Palermo A, Plummer MP, Rotherham H, Ramanan M, Reddi B, Reynolds C, Webb SA, Udy AA, Burrell A. Med J Aust. 2022 Jun 9. doi: 10.5694/mja2.51590. Epub ahead of print. PMID: 35686307.

Biomarkers of brain injury after cardiac arrest; a statistical analysis plan from the TTM2 trial biobank investigators. Moseby-Knappe M, Levin H, Blennow K, Ullén S, Zetterberg H, Lilja G, Dankiewicz J, Jakobsen JC, Lagebrant A, Friberg H, Nichol A, Ainschough K, Eastwood GM, Wise MP, Thomas M, Keeble T, Cariou A, Leithner C, Rylander C, Düring J, Bělohlávek J, Grejs A, Borgquist O, Undén J, Simon M, Rolny V, Piehler A, Cronberg T, Nielsen N. Resusc Plus. 2022 Jun 2;10:100258. doi: 10.1016/j.resplu.2022.100258. PMID: 35677835; PMCID: PMC9168690.

Association of Positive End-Expiratory Pressure and Lung Recruitment Selection Strategies with Mortality in Acute Respiratory Distress Syndrome: A Systematic Review and Network Meta-analysis. Dianti J, Tisminetzky M, Ferreyro BL, Englesakis M, Del Sorbo L, Sud S, Talmor D, Ball L, Meade M, Hodgson C, Beitler JR, Sahetya S, Nichol A, Fan E, Rochwerg B, Brochard L, Slutsky AS, Ferguson ND, Serpa Neto A, Adhikari NKJ, Angriman F, Goligher EC. Am J Respir Crit Care Med. 2022 Jun 1;205(11):1300-1310. doi: 10.1164/rccm.202108-1972OC. PMID: 35180042.

Development of the Consumer Involvement & Engagement Toolkit: a digital resource to build capacity for undertaking patient-centred clinical trials in Australia. Symons T, Bowden J, McKenzie A, Fallon-Ferguson JM, Weekes LY, Ansell J, Murphy R, Jesudason S, Saxena M, Nichol A, Straiton N. Public Health Res Pract. 2022 Jun 1:32122209. doi: 10.17061/phrp32122209. Online ahead of print. PMID: 35661863

Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study. Greco M, De Corte T, Ercole A, Antonelli M, Azoulay E, Citerio G, Morris AC, De Pascale G, Duska F, Elbers P, Einav S, Forni L, Galarza L, Girbes ARJ, Grasselli G, Gusarov V, Jubb A, Kesecioglu J, Lavinio A, Delgado MCM, Mellinghoff J, Myatra SN, Ostermann M, Pellegrini M, Povoa P, Schaller SJ, Teboul JL, Wong A, De Waele JJ, Cecconi M; ESICM UNITE-COVID investigators. Intensive Care Med. 2022 May 21:1-16. doi: 10.1007/s00134-022-06705-1. Online ahead of print. PMID: 35596752 Correction to: Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study. Intensive Care Med. 2022 Aug;48(8):1130-1131. doi: 10.1007/s00134-022-06801-2.

 

Early short course of neuromuscular blocking agents in patients with COVID-19 ARDS: a propensity score analysis. Li Bassi G, Gibbons K, Suen JY, Dalton HJ, White N, Corley A, Shrapnel S, Hinton S, Forsyth S, Laffey JG, Fan E, Fanning JP, Panigada M, Bartlett R, Brodie D, Burrell A, Chiumello D, Elhazmi A, Esperatti M, Grasselli G, Hodgson C, Ichiba S, Luna C, Marwali E, Merson L, Murthy S, Nichol A, Ogino M, Pelosi P, Torres A, Ng PY, Fraser JF; COVID-19 Critical Care Consortium. Crit Care. 2022 May 17;26(1):141. doi: 10.1186/s13054-022-03983-5. PMID: 35581612

Use of an extended KDIGO definition to diagnose acute kidney injury in patients with COVID-19: A multinational study using the ISARIC-WHO clinical characterisation protocol. Wainstein M, MacDonald S, Fryer D, Young K, Balan V, Begum H, Burrell A, Citarella BW, Cobb JP, Kelly S, Kennon K, Lee J, Merson L, Murthy S, Nichol A, Semple MG, Strudwick S, Webb SA, Rossignol P, Claure-Del Granado R, Shrapnel S; ISARIC Clinical Characterisation Group. PLoS Med. 2022 Apr 20;19(4):e1003969. doi: 10.1371/journal.pmed.1003969. Epub ahead of print. PMID: 35442972.

Effects of brain tissue oxygen (PbtO2) guided management on patient outcomes following severe traumatic brain injury: A systematic review and meta-analysis.Hays LMC, Udy A, Adamides AA, Anstey JR, Bailey M, Bellapart J, Byrne K, Cheng A, Jamie Cooper D, Drummond KJ, Haenggi M, Jakob SM, Higgins AM, Lewis PM, Hunn MK, McNamara R, Menon DK, Murray L, Reddi B, Trapani T, Vallance S, Young PJ, Diaz-Arrastia R, Shutter L, Murray PT, Curley GF, Nichol A. J Clin Neurosci. 2022 Mar 29;99:349-358. doi: 10.1016/j.jocn.2022.03.017. Epub ahead of print. PMID: 35364437.

Economic evaluations for intensive care unit randomised clinical trials in Australia and New Zealand: Practical recommendations for researchers.Taylor CB, Thompson KJ, Hodgson C PhD, Liew C MPH, Litton E MBChB, FCICM, PhD, McGain F FANZCA, FCICM, PhD, Nichol A PhD, Rauniyar R MPH, Ridley E PhD, Higgins A PhD. Aust Crit Care. 2022 Mar 24:S1036-7314(22)00028-5. doi: 10.1016/j.aucc.2022.02.002. Epub ahead of print. PMID: 35341668.

Impact of renin-angiotensin-aldosterone system inhibition on mortality in critically ill COVID-19 patients with pre-existing hypertension: a prospective cohort study.Sato K, White N, Fanning JP, Obonyo N, Yamashita MH, Appadurai V, Ciullo A, May M, Worku ET, Helms L, Ohshimo S, Juzar DA, Suen JY, Bassi GL, Fraser JF, Arora RC; COVID-19 Critical Care Consortium Investigators. BMC Cardiovasc Disord. 2022 Mar 23;22(1):123. doi: 10.1186/s12872-022-02565-1. PMID: 35321649; PMCID: PMC8942148.

Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial.REMAP-CAP Writing Committee for the REMAP-CAP Investigators, Bradbury CA, Lawler PR, Stanworth SJ, McVerry BJ, McQuilten Z, Higgins AM, Mouncey PR, Al-Beidh F, Rowan KM, Berry LR, Lorenzi E, Zarychanski R, Arabi YM, Annane D, Beane A, van Bentum-Puijk W, Bhimani Z, Bihari S, Bonten MJM, Brunkhorst FM, Buzgau A, Buxton M, Carrier M, Cheng AC, Cove M, Detry MA, Estcourt LJ, Fitzgerald M, Girard TD, Goligher EC, Goossens H, Haniffa R, Hills T, Huang DT, Horvat CM, Hunt BJ, Ichihara N, Lamontagne F, Leavis HL, Linstrum KM, Litton E, Marshall JC, McAuley DF, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Morpeth SC, Murthy S, Neal MD, Nichol AD, Parke RL, Parker JC, Reyes LF, Saito H, Santos MS, Saunders CT, Serpa-Neto A, Seymour CW, Shankar-Hari M, Singh V, Tolppa T, Turgeon AF, Turner AM, van de Veerdonk FL, Green C, Lewis RJ, Angus DC, McArthur CJ, Berry S, Derde LPG, Webb SA, Gordon AC. JAMA. 2022 Apr 5;327(13):1247-1259. doi: 10.1001/jama.2022.2910. PMID: 35315874.

 Whole genome sequencing reveals host factors underlying critical Covid-19.Kousathanas A, Pairo-Castineira E, Rawlik K, Stuckey A, Odhams CA, Walker S, Russell CD, Malinauskas T, Wu Y, Millar J, Shen X, Elliott KS, Griffiths F, Oosthuyzen W, Morrice K, Keating S, Wang B, Rhodes D, Klaric L, Zechner M, Parkinson N, Siddiq A, Goddard P, Donovan S, Maslove D, Nichol A, Semple MG, Zainy T, Maleady-Crowe F, Todd L, Salehi S, Knight J, Elgar G, Chan G, Arumugam P, Patch C, Rendon A, Bentley D, Kingsley C, Kosmicki JA, Horowitz JE, Baras A, Abecasis GR, Ferreira MAR, Justice A, Mirshahi T, Oetjens M, Rader DJ, Ritchie MD, Verma A, Fowler TA, Shankar-Hari M, Summers C, Hinds C, Horby P, Ling L, McAuley D, Montgomery H, Openshaw PJM, Elliott P, Walsh T, Tenesa A; GenOMICC Investigators; 23andMe; Covid-19 Human Genetics Initiative, Fawkes A, Murphy L, Rowan K, Ponting CP, Vitart V, Wilson JF, Yang J, Bretherick AD, Scott RH, Hendry SC, Moutsianas L, Law A, Caulfield MJ, Baillie JK. Nature. 2022 Mar 7. doi: 10.1038/s41586-022-04576-6. Epub ahead of print. PMID: 35255492.

Ventilation management and outcomes in out-of-hospital cardiac arrest: a protocol for a preplanned secondary analysis of the TTM2 trial.Robba C, Nielsen N, Dankiewicz J, Badenes R, Battaglini D, Ball L, Brunetti I, Pedro David WG, Young P, Eastwood G, Chew MS, Jakobsen J, Unden J, Thomas M, Joannidis M, Nichol A, Lundin A, Hollenberg J, Lilja G, Hammond NE, Saxena M, Martin A, Solar M, Taccone FS, Friberg HA, Pelosi P. BMJ Open. 2022 Mar 3;12(3):e058001. doi: 10.1136/bmjopen-2021-058001. PMID: 35241476; PMCID: PMC8896064.

Association of PEEP and Lung Recruitment Selection Strategies with Mortality in Acute Respiratory Distress Syndrome: A Systematic Review and Network Meta-Analysis. Dianti J, Tisminetzky M, Ferreyro BL, Englesakis M, Del Sorbo L, Sud S, Talmor D, Ball L, Meade M, Hodgson C, Beitler JR, Sahetya S, Nichol A, Fan E, Rochwerg B, Brochard L, Slutsky AS, Ferguson ND, Serpa Neto A, Adhikari NK, Angriman F, Goligher EC. Am J Respir Crit Care Med. 2022 Feb 18. doi: 10.1164/rccm.202108-1972OC. Epub ahead of print. PMID: 35180042.

Clinical characteristics, risk factors and outcomes in patients with severe COVID-19 registered in the International Severe Acute Respiratory and Emerging Infection Consortium WHO clinical characterisation protocol: a prospective, multinational, multicentre, observational study. Reyes LF, Murthy S, Garcia-Gallo E, Irvine M, Merson L, Martin-Loeches I, Rello J, Taccone FS, Fowler RA, Docherty AB, Kartsonaki C, Aragao I, Barrett PW, Beane A, Burrell A, Cheng MP, Christian MD, Cidade JP, Citarella BW, Donnelly CA, Fernandes SM, French C, Haniffa R, Harrison EM, Ho AYW, Joseph M, Khan I, Kho ME, Kildal AB, Kutsogiannis D, Lamontagne F, Lee TC, Bassi GL, Lopez Revilla JW, Marquis C, Millar J, Neto R, Nichol A, Parke R, Pereira R, Poli S, Povoa P, Ramanathan K, Rewa O, Riera J, Shrapnel S, Silva MJ, Udy A, Uyeki T, Webb SA, Wils EJ, Rojek A, Olliaro PL; ISARIC Clinical Characterisation Group. ERJ Open Res. 2022 Feb 14;8(1):00552-2021. doi: 10.1183/23120541.00552-2021. PMID: 35169585; PMCID: PMC8669808.

Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis. Maddali MV, Churpek M, Pham T, Rezoagli E, Zhuo H, Zhao W, He J, Delucchi KL, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Liu KD, Matthay MA, Ware LB, Laffey JG, Bellani G, Calfee CS, Sinha P; LUNG SAFE Investigators and the ESICM Trials Group. Lancet Respir Med. 2022 Apr;10(4):367-377. doi: 10.1016/S2213-2600(21)00461-6. Epub 2022 Jan 10. PMID: 35026177; PMCID: PMC8976729.

 

2021

Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies. Pisani L, Algera AG, Neto AS, Azevedo L, Pham T, Paulus F, de Abreu MG, Pelosi P, Dondorp AM, Bellani G, Laffey JG, Schultz MJ; ERICC study investigators; LUNG SAFE study investigators; PRoVENT study investigators; PRoVENT-iMiC study investigators. Lancet Glob Health. 2021 Dec 13:S2214-109X(21)00485-X. doi: 10.1016/S2214-109X(21)00485-X. Epub ahead of print. PMID: 34914899.

Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.Fallerini C, Picchiotti N, Baldassarri M, Zguro K, Daga S, Fava F, Benetti E, Amitrano S, Bruttini M, Palmieri M, Croci S, Lista M, Beligni G, Valentino F, Meloni I, Tanfoni M, Minnai F, Colombo F, Cabri E, Fratelli M, Gabbi C, Mantovani S, Frullanti E, Gori M, Crawley FP, Butler-Laporte G, Richards B, Zeberg H, Lipcsey M, Hultström M, Ludwig KU, Schulte EC, Pairo-Castineira E, Baillie JK, Schmidt A, Frithiof R; WES/WGS Working Group Within the HGI; GenOMICC Consortium; GEN-COVID Multicenter Study, Mari F, Renieri A, Furini S. Hum Genet. 2021 Dec 10:1–27. doi: 10.1007/s00439-021-02397-7. Epub ahead of print. PMID: 34889978; PMCID: PMC8661833.

Ten months of temporal variation in the clinical journey of hospitalised patients with COVID-19: An observational cohort. ISARIC Clinical Characterisation Group, Hall MD, Baruch J, Carson G, Citarella BW, Dagens A, Dankwa EA, Donnelly CA, Dunning J, Escher M, Kartsonaki C, Merson L, Pritchard M, Wei J, Horby PW, Rojek A, Olliaro PL. Elife. 2021 Nov 23;10:e70970. doi: 10.7554/eLife.70970. PMID: 34812731; PMCID: PMC8791638.

Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials.Axfors C, Janiaud P, Schmitt AM, …, Nichol AD, Nielsen H, Novak RM, O'Sullivan MVN, Olalla J, Osibogun A, Osikomaiya B, Oyonarte S, Pardo-Oviedo JM, Patel MC, Paterson DL, Peña-Perez CA, Perez-Calatayud AA, Pérez-Alba E, Perkina A, Perry N, Pouladzadeh M, Poyato I, Price DJ, Quero AKH, Rahman MM, Rahman MS, Ramesh M, Ramírez-Santana C, Rasmussen M, Rees MA, Rego E, Roberts JA, Roberts DJ, Rodríguez Y, Rodríguez-Baño J, Rogers BA, Rojas M, Romero A, Rowan KM, Saccona F, Safdarian M, Santos MCM, Sasadeusz J, Scozzari G, Shankar-Hari M, Sharma G, Snelling T, Soto A, Tagayuna PY, Tang A, Tatem G, Teofili L, Tong SYC, Turgeon AF, Veloso JD, Venkatesh B, Ventura-Enriquez Y, Webb SA, Wiese L, Wikén C, Wood EM, Yusubalieva GM, Zacharowski K, Zarychanski R, Khanna N, Moher D, Goodman SN, Ioannidis JPA, Hemkens LG. BMC Infect Dis. 2021 Nov 20;21(1):1170. doi: 10.1186/s12879-021-06829-7. PMID: 34800996; PMCID: PMC8605464.

Assessment of 28-Day In-Hospital Mortality in Mechanically Ventilated Patients With Coronavirus Disease 2019: An International Cohort Study.Li Bassi G, Suen JY, White N, Dalton HJ, Fanning J, Corley A, Shrapnel S, Hinton S, Forsyth S, Parsons R, Laffey JG, Fan E, Bartlett R, Brodie D, Burrell A, Chiumello D, Elhazmi A, Grasselli G, Hodgson C, Ichiba S, Luna C, Marwali E, Merson L, Murthy S, Nichol A, Panigada M, Pelosi P, Torres A, Ng PY, Ogino M, Fraser JF. Crit Care Explor. 2021 Nov 5;3(11):e0567. doi: 10.1097/CCE.0000000000000567. PMID: 34765979; PMCID: PMC8575423.

The value of open-source clinical science in pandemic response: lessons from ISARIC. ISARIC Clinical Characterisation Group. Lancet Infect Dis. 2021 Dec;21(12):1623-1624. doi: 10.1016/S1473-3099(21)00565-X. Epub 2021 Oct 4. Erratum in: Lancet Infect Dis. 2021 Dec;21(12):e363. PMID: 34619109; PMCID: PMC8489876.

Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial.Writing Committee for the REMAP-CAP Investigators, Estcourt LJ, Turgeon AF, McQuilten ZK, McVerry BJ, Al-Beidh F, Annane D, Arabi YM, Arnold DM, Beane A, Bégin P, van Bentum-Puijk W, Berry LR, Bhimani Z, Birchall JE, Bonten MJM, Bradbury CA, Brunkhorst FM, Buxton M, Callum JL, Chassé M, Cheng AC, Cove ME, Daly J, Derde L, Detry MA, De Jong M, Evans A, Fergusson DA, Fish M, Fitzgerald M, Foley C, Goossens H, Gordon AC, Gosbell IB, Green C, Haniffa R, Harvala H, Higgins AM, Hills TE, Hoad VC, Horvat C, Huang DT, Hudson CL, Ichihara N, Laing E, Lamikanra AA, Lamontagne F, Lawler PR, Linstrum K, Litton E, Lorenzi E, MacLennan S, Marshall J, McAuley DF, McDyer JF, McGlothlin A, McGuinness S, Miflin G, Montgomery S, Mouncey PR, Murthy S, Nichol A, Parke R, Parker JC, Priddee N, Purcell DFJ, Reyes LF, Richardson P, Robitaille N, Rowan KM, Rynne J, Saito H, Santos M, Saunders CT, Serpa Neto A, Seymour CW, Silversides JA, Tinmouth AA, Triulzi DJ, Turner AM, van de Veerdonk F, Walsh TS, Wood EM, Berry S, Lewis RJ, Menon DK, McArthur C, Zarychanski R, Angus DC, Webb SA, Roberts DJ, Shankar-Hari M. JAMA. 2021 Nov 2;326(17):1690-1702. doi: 10.1001/jama.2021.18178. PMID: 34606578

Normalising comparative effectiveness trials as clinical practice.Briffa T, Symons T, Zeps N, Straiton N, Tarnow-Mordi WO, Simes J, Harris IA, Cruz M, Webb SA, Litton E, Nichol A, Williams CM. Trials. 2021 Sep 15;22(1):620. doi: 10.1186/s13063-021-05566-1. PMID: 34526083; PMCID: PMC8442385.

Urinary biomarkers predict progression and adverse outcomes of acute kidney injury in critical illness. Duff S, Irwin R, Cote JM, Redahan L, McMahon BA, Marsh B, Nichol A, Holden S, Doran P, Murray PT. Nephrol Dial Transplant. 2021 Sep 7:gfab263. doi: 10.1093/ndt/gfab263. Epub ahead of print. PMID: 34491355.

Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial.Ehrmann S, Li J, Ibarra-Estrada M, Perez Y, Pavlov I, McNicholas B, Roca O, Mirza S, Vines D, Garcia-Salcido R, Aguirre-Avalos G, Trump MW, Nay MA, Dellamonica J, Nseir S, Mogri I, Cosgrave D, Jayaraman D, Masclans JR, Laffey JG, Tavernier E; Awake Prone Positioning Meta-Trial Group. Lancet Respir Med. 2021 Aug 20:S2213-2600(21)00356-8. doi: 10.1016/S2213-2600(21)00356-8. Epub ahead of print. PMID: 34425070; PMCID: PMC8378833.

A multicenter randomized clinical trial of pharmacological vitamin B1 administration to critically ill patients who develop hypophosphatemia during enteral nutrition (The THIAMINE 4 HYPOPHOSPHATEMIA trial). Deane AM, Jiang A, Tascone B, Clancy A, Finnis ME, Collie JT, Greaves R, Byrne KM, Fujii T, Douglas JS, Nichol A, Udy AA, Young M, Russo G, Fetterplace K, Maiden MJ, Plummer MP, Yanase F, Bellomo R, Ali Abdelhamid Y. Clin Nutr. 2021 Jul 24;40(8):5047-5052. doi: 10.1016/j.clnu.2021.07.024. Epub ahead of print. PMID: 34388414.

Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19. REMAP-CAP Investigators; ACTIV-4a Investigators; ATTACC Investigators, Goligher EC, Bradbury CA, McVerry BJ, Lawler PR, Berger JS, Gong MN, Carrier M, Reynolds HR, Kumar A, Turgeon AF, Kornblith LZ, Kahn SR, Marshall JC, Kim KS, Houston BL, Derde LPG, Cushman M, Tritschler T, Angus DC, Godoy LC, McQuilten Z, Kirwan BA, Farkouh ME, Brooks MM, Lewis RJ, Berry LR, Lorenzi E, Gordon AC, Ahuja T, Al-Beidh F, Annane D, Arabi YM, Aryal D, Baumann Kreuziger L, Beane A, Bhimani Z, Bihari S, Billett HH, Bond L, Bonten M, Brunkhorst F, Buxton M, Buzgau A, Castellucci LA, Chekuri S, Chen JT, Cheng AC, Chkhikvadze T, Coiffard B, Contreras A, Costantini TW, de Brouwer S, Detry MA, Duggal A, Džavík V, Effron MB, Eng HF, Escobedo J, Estcourt LJ, Everett BM, Fergusson DA, Fitzgerald M, Fowler RA, Froess JD, Fu Z, Galanaud JP, Galen BT, Gandotra S, Girard TD, Goodman AL, Goossens H, Green C, Greenstein YY, Gross PL, Haniffa R, Hegde SM, Hendrickson CM, Higgins AM, Hindenburg AA, Hope AA, Horowitz JM, Horvat CM, Huang DT, Hudock K, Hunt BJ, Husain M, Hyzy RC, Jacobson JR, Jayakumar D, Keller NM, Khan A, Kim Y, Kindzelski A, King AJ, Knudson MM, Kornblith AE, Kutcher ME, Laffan MA, Lamontagne F, Le Gal G, Leeper CM, Leifer ES, Lim G, Gallego Lima F, Linstrum K, Litton E, Lopez-Sendon J, Lother SA, Marten N, Saud Marinez A, Martinez M, Mateos Garcia E, Mavromichalis S, McAuley DF, McDonald EG, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Mouncey PR, Murthy S, Nair GB, Nair R, Nichol AD, Nicolau JC, Nunez-Garcia B, Park JJ, Park PK, Parke RL, Parker JC, Parnia S, Paul JD, Pompilio M, Quigley JG, Rosenson RS, Rost NS, Rowan K, Santos FO, Santos M, Santos MO, Satterwhite L, Saunders CT, Schreiber J, Schutgens REG, Seymour CW, Siegal DM, Silva DG Jr, Singhal AB, Slutsky AS, Solvason D, Stanworth SJ, Turner AM, van Bentum-Puijk W, van de Veerdonk FL, van Diepen S, Vazquez-Grande G, Wahid L, Wareham V, Widmer RJ, Wilson JG, Yuriditsky E, Zhong Y, Berry SM, McArthur CJ, Neal MD, Hochman JS, Webb SA, Zarychanski R. N Engl J Med. 2021 Aug 4. doi: 10.1056/NEJMoa2103417. Epub ahead of print. PMID: 34351722.

Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19. ATTACC Investigators; ACTIV-4a Investigators; REMAP-CAP Investigators, Lawler PR, Goligher EC, Berger JS, Neal MD, McVerry BJ, Nicolau JC, Gong MN, Carrier M, Rosenson RS, Reynolds HR, Turgeon AF, Escobedo J, Huang DT, Bradbury CA, Houston BL, Kornblith LZ, Kumar A, Kahn SR, Cushman M, McQuilten Z, Slutsky AS, Kim KS, Gordon AC, Kirwan BA, Brooks MM, Higgins AM, Lewis RJ, Lorenzi E, Berry SM, Berry LR, Aday AW, Al-Beidh F, Annane D, Arabi YM, Aryal D, Baumann Kreuziger L, Beane A, Bhimani Z, Bihari S, Billett HH, Bond L, Bonten M, Brunkhorst F, Buxton M, Buzgau A, Castellucci LA, Chekuri S, Chen JT, Cheng AC, Chkhikvadze T, Coiffard B, Costantini TW, de Brouwer S, Derde LPG, Detry MA, Duggal A, Džavík V, Effron MB, Estcourt LJ, Everett BM, Fergusson DA, Fitzgerald M, Fowler RA, Galanaud JP, Galen BT, Gandotra S, García-Madrona S, Girard TD, Godoy LC, Goodman AL, Goossens H, Green C, Greenstein YY, Gross PL, Hamburg NM, Haniffa R, Hanna G, Hanna N, Hegde SM, Hendrickson CM, Hite RD, Hindenburg AA, Hope AA, Horowitz JM, Horvat CM, Hudock K, Hunt BJ, Husain M, Hyzy RC, Iyer VN, Jacobson JR, Jayakumar D, Keller NM, Khan A, Kim Y, Kindzelski AL, King AJ, Knudson MM, Kornblith AE, Krishnan V, Kutcher ME, Laffan MA, Lamontagne F, Le Gal G, Leeper CM, Leifer ES, Lim G, Lima FG, Linstrum K, Litton E, Lopez-Sendon J, Lopez-Sendon Moreno JL, Lother SA, Malhotra S, Marcos M, Saud Marinez A, Marshall JC, Marten N, Matthay MA, McAuley DF, McDonald EG, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Moore SC, Morillo Guerrero R, Mouncey PR, Murthy S, Nair GB, Nair R, Nichol AD, Nunez-Garcia B, Pandey A, Park PK, Parke RL, Parker JC, Parnia S, Paul JD, Pérez González YS, Pompilio M, Prekker ME, Quigley JG, Rost NS, Rowan K, Santos FO, Santos M, Olombrada Santos M, Satterwhite L, Saunders CT, Schutgens REG, Seymour CW, Siegal DM, Silva DG Jr, Shankar-Hari M, Sheehan JP, Singhal AB, Solvason D, Stanworth SJ, Tritschler T, Turner AM, van Bentum-Puijk W, van de Veerdonk FL, van Diepen S, Vazquez-Grande G, Wahid L, Wareham V, Wells BJ, Widmer RJ, Wilson JG, Yuriditsky E, Zampieri FG, Angus DC, McArthur CJ, Webb SA, Farkouh ME, Hochman JS, Zarychanski R. N Engl J Med. 2021 Aug 4. doi: 10.1056/NEJMoa2105911. Epub ahead of print. PMID: 34351721.

Inflammation, immunity and allergy. Stewart, D., Nichol, A. Anaesthesia and Intensive Care Medicine. 2021 Aug;22(8):488-493. DOI: 10.1016/j.mpaic.2021.06.004

Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial. Arabi YM, Gordon AC, Derde LPG, Nichol AD, Murthy S, Beidh FA, Annane D, Swaidan LA, Beane A, Beasley R, Berry LR, Bhimani Z, Bonten MJM, Bradbury CA, Brunkhorst FM, Buxton M, Buzgau A, Cheng A, De Jong M, Detry MA, Duffy EJ, Estcourt LJ, Fitzgerald M, Fowler R, Girard TD, Goligher EC, Goossens H, Haniffa R, Higgins AM, Hills TE, Horvat CM, Huang DT, King AJ, Lamontagne F, Lawler PR, Lewis R, Linstrum K, Litton E, Lorenzi E, Malakouti S, McAuley DF, McGlothlin A, Mcguinness S, McVerry BJ, Montgomery SK, Morpeth SC, Mouncey PR, Orr K, Parke R, Parker JC, Patanwala AE, Rowan KM, Santos MS, Saunders CT, Seymour CW, Shankar-Hari M, Tong SYC, Turgeon AF, Turner AM, Van de Veerdonk FL, Zarychanski R, Green C, Berry S, Marshall JC, McArthur C, Angus DC, Webb SA; REMAP-CAP Investigators. Intensive Care Med. 2021 Jul 12:1–20. doi: 10.1007/s00134-021-06448-5. Epub ahead of print. PMID: 34251506; PMCID: PMC8274471.

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study. ISARIC Clinical Characterisation Group. Infection. 2021 Jun 25:1–17. doi: 10.1007/s15010-021-01599-5. Epub ahead of print. PMID: 34170486; PMCID: PMC8231091.

Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest.Dankiewicz J, Cronberg T, Lilja G, Jakobsen JC, Levin H, Ullén S, Rylander C, Wise MP, Oddo M, Cariou A, Bělohlávek J, Hovdenes J, Saxena M, Kirkegaard H, Young PJ, Pelosi P, Storm C, Taccone FS, Joannidis M, Callaway C, Eastwood GM, Morgan MPG, Nordberg P, Erlinge D, Nichol AD, Chew MS, Hollenberg J, Thomas M, Bewley J, Sweet K, Grejs AM, Christensen S, Haenggi M, Levis A, Lundin A, Düring J, Schmidbauer S, Keeble TR, Karamasis GV, Schrag C, Faessler E, Smid O, Otáhal M, Maggiorini M, Wendel Garcia PD, Jaubert P, Cole JM, Solar M, Borgquist O, Leithner C, Abed-Maillard S, Navarra L, Annborn M, Undén J, Brunetti I, Awad A, McGuigan P, Bjørkholt Olsen R, Cassina T, Vignon P, Langeland H, Lange T, Friberg H, Nielsen N; TTM2 Trial Investigators. N Engl J Med. 2021 Jun 17;384(24):2283-2294. doi: 10.1056/NEJMoa2100591. PMID: 34133859.

An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients. Li Bassi G, Suen JY, Dalton HJ, White N, Shrapnel S, Fanning JP, Liquet B, Hinton S, Vuorinen A, Booth G, Millar JE, Forsyth S, Panigada M, Laffey J, Brodie D, Fan E, Torres A, Chiumello D, Corley A, Elhazmi A, Hodgson C, Ichiba S, Luna C, Murthy S, Nichol A, Ng PY, Ogino M, Pesenti A, Trieu HT, Fraser JF; COVID-19 Critical Care Consortium. Crit Care. 2021 Jun 9;25(1):199. doi: 10.1186/s13054-021-03518-4. PMID: 34108029; PMCID: PMC8188162.

Preparing accessible and understandable clinical research participant information leaflets and consent forms: a set of guidelines from an expert consensus conference. Coleman E, O'Sullivan L, Crowley R, Hanbidge M, Driver S, Kroll T, Kelly A, Nichol A, McCarthy O, Sukumar P, Doran P. Res Involv Engagem. 2021 May 18;7(1):31. doi: 10.1186/s40900-021-00265-2. PMID: 34006326; PMCID: PMC8130271.

Integration of Equipoise into Eligibility Criteria in the STARRT-AKI Trial. Wald R, Bagshaw SM; STARRT-AKI Investigators. Am J Respir Crit Care Med. 2021 May 3. doi: 10.1164/rccm.202009-3425LE. Epub ahead of print. PMID: 33939598.

Diabetes and Overweight/Obesity Are Independent, Nonadditive Risk Factors for In-Hospital Severity of COVID-19: An International, Multicenter Retrospective Meta-analysis. Longmore DK, Miller JE, Bekkering S, Saner C, Mifsud E, Zhu Y, Saffery R, Nichol A, Colditz G, Short KR, Burgner DP; International BMI-COVID consortium; *International BMI-COVID consortium. Diabetes Care. 2021 Apr 15:dc202676. doi: 10.2337/dc20-2676. Epub ahead of print. PMID: 33858854.

Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials.Axfors C, Schmitt AM, Janiaud P, Van't Hooft J, Abd-Elsalam S, Abdo EF, Abella BS, Akram J, Amaravadi RK, Angus DC, Arabi YM, Azhar S, Baden LR, Baker AW, Belkhir L, Benfield T, Berrevoets MAH, Chen CP, Chen TC, Cheng SH, Cheng CY, Chung WS, Cohen YZ, Cowan LN, Dalgard O, de Almeida E Val FF, de Lacerda MVG, de Melo GC, Derde L, Dubee V, Elfakir A, Gordon AC, Hernandez-Cardenas CM, Hills T, Hoepelman AIM, Huang YW, Igau B, Jin R, Jurado-Camacho F, Khan KS, Kremsner PG, Kreuels B, Kuo CY, Le T, Lin YC, Lin WP, Lin TH, Lyngbakken MN, McArthur C, McVerry BJ, Meza-Meneses P, Monteiro WM, Morpeth SC, Mourad A, Mulligan MJ, Murthy S, Naggie S, Narayanasamy S, Nichol A, Novack LA, O'Brien SM, Okeke NL, Perez L, Perez-Padilla R, Perrin L, Remigio-Luna A, Rivera-Martinez NE, Rockhold FW, Rodriguez-Llamazares S, Rolfe R, Rosa R, Røsjø H, Sampaio VS, Seto TB, Shehzad M, Soliman S, Stout JE, Thirion-Romero I, Troxel AB, Tseng TY, Turner NA, Ulrich RJ, Walsh SR, Webb SA, Weehuizen JM, Velinova M, Wong HL, Wrenn R, Zampieri FG, Zhong W, Moher D, Goodman SN, Ioannidis JPA, Hemkens LG. Nat Commun. 2021 Apr 15;12(1):2349. doi: 10.1038/s41467-021-22446-z. PMID: 33859192. Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials. Nat Commun. 2021 May 14;12(1):3001. doi: 10.1038/s41467-021-23559-1. Erratum for: Nat Commun. 2021 Apr 15;12(1):2349. PMID: 33990619; PMCID: PMC8121133.

Death in hospital following ICU discharge: insights from the LUNG SAFE study.Madotto F, McNicholas B, Rezoagli E, Pham T, Laffey JG, Bellani G; LUNG SAFE Investigators; ESICM Trials Group. Crit Care. 2021 Apr 13;25(1):144. doi: 10.1186/s13054-021-03465-0. PMID: 33849625; PMCID: PMC8043098.

Early sedation with dexmedetomidine in ventilated critically ill patients and heterogeneity of treatment effect in the SPICE III randomised controlled trial. Shehabi Y, Serpa Neto A, Howe BD, Bellomo R, Arabi YM, Bailey M, Bass FE, Kadiman SB, McArthur CJ, Reade MC, Seppelt IM, Takala J, Wise MP, Webb SA; SPICE III Study Investigators. Intensive Care Med. 2021 Mar 8:1–12. doi: 10.1007/s00134-021-06356-8. Epub ahead of print. PMID: 33686482; PMCID: PMC7939103.

Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19.REMAP-CAP Investigators, Gordon AC, Mouncey PR, Al-Beidh F, Rowan KM, Nichol AD, Arabi YM, Annane D, Beane A, van Bentum-Puijk W, Berry LR, Bhimani Z, Bonten MJM, Bradbury CA, Brunkhorst FM, Buzgau A, Cheng AC, Detry MA, Duffy EJ, Estcourt LJ, Fitzgerald M, Goossens H, Haniffa R, Higgins AM, Hills TE, Horvat CM, Lamontagne F, Lawler PR, Leavis HL, Linstrum KM, Litton E, Lorenzi E, Marshall JC, Mayr FB, McAuley DF, McGlothlin A, McGuinness SP, McVerry BJ, Montgomery SK, Morpeth SC, Murthy S, Orr K, Parke RL, Parker JC, Patanwala AE, Pettilä V, Rademaker E, Santos MS, Saunders CT, Seymour CW, Shankar-Hari M, Sligl WI, Turgeon AF, Turner AM, van de Veerdonk FL, Zarychanski R, Green C, Lewis RJ, Angus DC, McArthur CJ, Berry S, Webb SA, Derde LPG. N Engl J Med. 2021 Feb 25. doi: 10.1056/NEJMoa2100433. Online ahead of print. PMID: 33631065

A Post Hoc Analysis of Osmotherapy Use in the Erythropoietin in Traumatic Brain Injury Study-Associations With Acute Kidney Injury and Mortality.Skrifvars MB, Bailey M, Moore E, Mårtensson J, French C, Presneill J, Nichol A, Little L, Duranteau J, Huet O, Haddad S, Arabi YM, McArthur C, Cooper DJ, Bendel S, Bellomo R; Erythropoietin in Traumatic Brain Injury (EPO-TBI) Investigators and the Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group. Crit Care Med. 2021 Jan 20. doi: 10.1097/CCM.0000000000004853. Online ahead of print. PMID: 33566466

Incidence and management of metabolic acidosis with sodium bicarbonate in the ICU: An international observational study.Fujii T, Udy AA, Nichol A, Bellomo R, Deane AM, El-Khawas K, Thummaporn N, Serpa Neto A, Bergin H, Short-Burchell R, Chen CM, Cheng KH, Cheng KC, Chia C, Chiang FF, Chou NK, Fazio T, Fu PK, Ge V, Hayashi Y, Holmes J, Hu TY, Huang SF, Iguchi N, Jones SL, Karumai T, Katayama S, Ku SC, Lai CL, Lee BJ, Liaw WJ, Ong CTW, Paxton L, Peppin C, Roodenburg O, Saito S, Santamaria JD, Shehabi Y, Tanaka A, Tiruvoipati R, Tsai HE, Wang AY, Wang CY, Yeh YC, Yu CJ, Yuan KC; SODA-BIC investigators. Crit Care. 2021 Feb 2;25(1):45. doi: 10.1186/s13054-020-03431-2. PMID: 33531020

Acute kidney injury and the critically ill.Flood L, Nichol A. Anaesthesia and Intensive Care Medicine. 2021 Jan;22(2):121-127. DOI: 10.1016/j.mpaic.2020.12.004

Care bundles for improving outcomes in patients with COVID-19 or related conditions in intensive care - a rapid scoping review. Smith V, Devane D, Nichol A, Roche D. Cochrane Database Syst Rev. 2020 Dec 21;12:CD013819. doi: 10.1002/14651858.CD013819. PMID: 33348427

Outcomes for patients with COVID-19 admitted to Australian intensive care units during the first four months of the pandemic. Burrell AJ, Pellegrini B, Salimi F, Begum H, Broadley T, Campbell LT, Cheng AC, Cheung W, Cooper DJ, Earnest A, Erickson SJ, French CJ, Kaldor JM, Litton E, Murthy S, McAllister RE, Nichol AD, Palermo A, Plummer MP, Ramanan M, Reddi BA, Reynolds C, Trapani T, Webb SA, Udy AA. Med J Aust. 2021 Jan;214(1):23-30. doi: 10.5694/mja2.50883. Epub 2020 Dec 15. PMID: 33325070

 

2020

The environmental impact of unused anaesthetic face mask hook rings
Keane RM, Angelov S, Burlacu C. Mesentery Peritoneum 2020;4:AB114.​

Genetic mechanisms of critical illness in Covid-19. Pairo-Castineira E, Clohisey S, Klaric L, Bretherick AD, Rawlik K, Pasko D, Walker S, Parkinson N, Fourman MH, Russell CD, Furniss J, Richmond A, Gountouna E, Wrobel N, Harrison D, Wang B, Wu Y, Meynert A, Griffiths F, Oosthuyzen W, Kousathanas A, Moutsianas L, Yang Z, Zhai R, Zheng C, Grimes G, Beale R, Millar J, Shih B, Keating S, Zechner M, Haley C, Porteous DJ, Hayward C, Yang J, Knight J, Summers C, Shankar-Hari M, Klenerman P, Turtle L, Ho A, Moore SC, Hinds C, Horby P, Nichol A, Maslove D, Ling L, McAuley D, Montgomery H, Walsh T, Pereira A, Renieri A; GenOMICC Investigators; ISARICC Investigators; COVID-19 Human Genetics Initiative; 23andMe Investigators; BRACOVID Investigators; Gen-COVID Investigators, Shen X, Ponting CP, Fawkes A, Tenesa A, Caulfield M, Scott R, Rowan K, Murphy L, Openshaw PJM, Semple MG, Law A, Vitart V, Wilson JF, Baillie JK. Nature. 2020 Dec 11. doi: 10.1038/s41586-020-03065-y. Online ahead of print. PMID: 33307546

 

Clinician-researcher's perspectives on clinical research during the COVID19 pandemic. Silverberg SL, Puchalski Ritchie LM, Gobat N, Nichol A, Murthy S. PLoS One. 2020 Dec 9;15(12):e0243525. doi: 10.1371/journal.pone.0243525. eCollection 2020. PMID: 33296427

Facing the Ethical Challenges: Consumer Involvement in COVID-19 Pandemic Research. Straiton N, McKenzie A, Bowden J, Nichol A, Murphy R, Snelling T, Zalcberg J, Clements J, Stubbs J, Economides A, Kent D, Ansell J, Symons T.  J Bioeth Inq. 2020 Nov 9:1–6. doi: 10.1007/s11673-020-10060-5. Epub ahead of print. PMID: 33169265; PMCID: PMC7651817.

Targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest: a statistical analysis plan. Jakobsen JC, Dankiewicz J, Lange T, Cronberg T, Lilja G, Levin H, Bělohlávek J, Callaway C, Cariou A, Erlinge D, Hovdenes J, Joannidis M, Nordberg P, Oddo M, Pelosi P, Kirkegaard H, Eastwood G, Rylander C, Saxena M, Storm C, Taccone FS, Wise MP, Morgan MPG, Young P, Nichol A, Friberg H, Ullén S, Nielsen N. Trials. 2020 Oct 7;21(1):831. doi: 10.1186/s13063-020-04654-y. PMID: 33028425

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial. Writing Committee for the REMAP-CAP Investigators, Angus DC, Derde L, Al-Beidh F, Annane D, Arabi Y, Beane A, van Bentum-Puijk W, Berry L, Bhimani Z, Bonten M, Bradbury C, Brunkhorst F, Buxton M, Buzgau A, Cheng AC, de Jong M, Detry M, Estcourt L, Fitzgerald M, Goossens H, Green C, Haniffa R, Higgins AM, Horvat C, Hullegie SJ, Kruger P, Lamontagne F, Lawler PR, Linstrum K, Litton E, Lorenzi E, Marshall J, McAuley D, McGlothin A, McGuinness S, McVerry B, Montgomery S, Mouncey P, Murthy S, Nichol A, Parke R, Parker J, Rowan K, Sanil A, Santos M, Saunders C, Seymour C, Turner A, van de Veerdonk F, Venkatesh B, Zarychanski R, Berry S, Lewis RJ, McArthur C, Webb SA, Gordon AC. JAMA. 2020 Oct 6;324(13):1317-1329. doi: 10.1001/jama.2020.17022. PMID: 32876697

Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury. STARRT-AKI Investigators; Canadian Critical Care Trials Group, the Australian and New Zealand Intensive Care Society Clinical Trials Group, the United Kingdom Critical Care Research Group, the Canadian Nephrology Trials Network, and the Irish Critical Care Trials Group, Bagshaw SM, Wald R, Adhikari NKJ, Bellomo R, da Costa BR, Dreyfuss D, Du B, Gallagher MP, Gaudry S, Hoste EA, Lamontagne F, Joannidis M, Landoni G, Liu KD, McAuley DF, McGuinness SP, Neyra JA, Nichol AD, Ostermann M, Palevsky PM, Pettilä V, Quenot JP, Qiu H, Rochwerg B, Schneider AG, Smith OM, Thomé F, Thorpe KE, Vaara S, Weir M, Wang AY, Young P, Zarbock A. N Engl J Med. 2020 Jul 16;383(3):240-251. doi: 10.1056/NEJMoa2000741. PMID: 32668114

 

Emerging pharmacological therapies for ARDS: COVID-19 and beyond.  Horie S, McNicholas B, Rezoagli E, Pham T, Curley G, McAuley D, O'Kane C, Nichol A, Dos Santos C, Rocco PRM, Bellani G, Laffey JG. Intensive Care Med. 2020 Jul 11:1-19. doi: 10.1007/s00134-020-06141-z. Online ahead of print. PMID: 32654006

Global outbreak research: harmony not hegemony. ISARIC clinical characterisation group. Lancet Infect Dis. 2020 Jul;20(7):770-772. doi: 10.1016/S1473-3099(20)30440-0. Epub 2020 Jun 2. PMID: 32502433

Optimal ventilator settings after return of spontaneous circulation.  Eastwood GM, Nichol A. Curr Opin Crit Care. 2020 Jun;26(3):251-258. doi: 10.1097/MCC.0000000000000720. PMID: 32348093

Opportunities and challenges of clustering, crossing over, and using registry data in the PEPTIC trial. Young PJ, Bagshaw SM, Forbes AB, Nichol AD, Wright SE, Bellomo R, van Haren F, Litton E, Webb SA. Crit Care Resusc. 2020 Jun;22(2):105-109. PMID: 32389102

In-Depth Extracorporeal Cardiopulmonary Resuscitation in Adult Out-of-Hospital Cardiac Arrest.  Dennis M, Lal S, Forrest P, Nichol A, Lamhaut L, Totaro RJ, Burns B, Sandroni C. J Am Heart Assoc. 2020 May 18;9(10):e016521. doi: 10.1161/JAHA.120.016521. Epub 2020 May 6. PMID: 32375010

ANZICS guiding principles for complex decision making during the COVID-19 pandemic.  Warrillow S, Austin D, Cheung W, Close E, Holley A, Horgan B, Jansen M, Joynt G, Lister P, Moodie S, Nichol A, Nicholls M, Peake S, Skowronski G, Streat S, White B, Willmott L. Crit Care Resusc. 2020 Apr 15. Online ahead of print. PMID: 32294810

The Randomized Embedded Multifactorial Adaptive Platform for Community-acquired Pneumonia (REMAP-CAP) Study: Rationale and Design.  Angus DC, Berry S, Lewis RJ, Al-Beidh F, Arabi Y, van Bentum-Puijk W, Bhimani Z, Bonten M, Broglio K, Brunkhorst F, Cheng AC, Chiche JD, De Jong M, Detry M, Goossens H, Gordon A, Green C, Higgins AM, Hullegie SJ, Kruger P, Lamontagne F, Litton E, Marshall J, McGlothlin A, McGuinness S, Mouncey P, Murthy S, Nichol A, O'Neill GK, Parke R, Parker J, Rohde G, Rowan K, Turner A, Young P, Derde L, McArthur C, Webb SA. Ann Am Thorac Soc. 2020 Apr 8. doi: 10.1513/AnnalsATS.202003-192SD. Online ahead of print. PMID: 32267771

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome: insights from the LUNG SAFE study.  Madotto F, Rezoagli E, Pham T, Schmidt M, McNicholas B, Protti A, Panwar R, Bellani G, Fan E, van Haren F, Brochard L, Laffey JG; LUNG SAFE Investigators and the ESICM Trials Group. Crit Care. 2020 Mar 31;24(1):125. doi: 10.1186/s13054-020-2826-6. PMID: 32234077

Characteristics and Outcomes of Critically Ill Trauma Patients in Australia and New Zealand (2005-2017).Wilson AJ, Magee F, Bailey M, Pilcher DV, French C, Nichol A, Udy A, Hodgson CL, Cooper DJ, Reade MC, Young P, Bellomo R. Crit Care Med. 2020 Feb 27. doi: 10.1097/CCM.0000000000004284. [Epub ahead of print] PMID: 32108705

The implications of the PEPTIC trial for clinical practice. Young PJ, Bagshaw SM, Bellomo R, Nichol AD, Wright SE. Crit Care Resusc. 2020 Mar;22(1):4-5. PMID: 32102637

Gender differences in mortality and quality of life after septic shock: A post-hoc analysis of the ARISE study. Nora Luethi, Michael Bailey, Alisa Higgins, Belinda Howe, Sandra Peake, Anthony Delaney, Rinaldo Bellomo, ARISE investigators.  J Crit Care. 2020;55:177-183. doi:10.1016/j.jcrc.2019.11.002 PMID: 31739087

Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation: The PEPTIC Randomized Clinical Trial. PEPTIC Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group, Alberta Health Services Critical Care Strategic Clinical Network, and the Irish Critical Care Trials Group, Young PJ, Bagshaw SM, Forbes AB, Nichol AD, Wright SE, Bailey M, Bellomo R, Beasley R, Brickell K, Eastwood GM, Gattas DJ, van Haren F, Litton E, Mackle DM, McArthur CJ, McGuinness SP, Mouncey PR, Navarra L, Opgenorth D, Pilcher D, Saxena MK, Webb SA, Wiley D, Rowan KM. JAMA. 2020 Jan 17. doi: 10.1001/jama.2019.22190. [Epub ahead of print]PMID: 31950977

 

2019

The effect of a low-dose naloxone infusion on the incidence of respiratory depression after intrathecal morphine administration for major open hepatobiliary surgery: a randomised controlled trial. Cosgrave D, Vencken S, Galligan M, McGuinness S, Soukhin E, McMullan V, Hussain R, Conlon N, Doran P, Nichol A. Anaesthesia. 2019 Dec 2. doi: 10.1111/anae.14931. [Epub ahead of print]PMID: 31792949

O2, do we know what to do?Young PJ, Bagshaw SM, Bailey M, Bellomo R, Mackle D, Pilcher D, Landoni G, Nichol A, Martin D. Crit Care Resusc. 2019 Dec;21(4):230-32.  PMID: 31778627

What the public think about participation in medical research during an influenza pandemic: an international cross-sectional survey. N. Gobat, C.C. Butler, J. Mollison, N.A. Francis, M. Gal, V. Harris, S.A.R. Webb, J.-P. Byrne, A. Watkins, P. Sukumar, K. Hood, A. Nichol. Public Health. 2019 Sep 23;177:80-94. doi: 10.1016/j.puhe.2019.07.005. PMID: 31557667

Targeted hypothermia versus targeted Normothermia after out-of-hospital cardiac arrest (TTM2): A randomized clinical trial-Rationale and design. Dankiewicz J, Cronberg T, Lilja G, Jakobsen JC, Bělohlávek J, Callaway C, Cariou A, Eastwood G, Erlinge D, Hovdenes J, Joannidis M, Kirkegaard H, Kuiper M, Levin H, Morgan MPG, Nichol AD, Nordberg P, Oddo M, Pelosi P, Rylander C, Saxena M, Storm C, Taccone F, Ullén S, Wise MP, Young P, Friberg H, Nielsen N. Am Heart J. 2019 Jun 26;217:23-31. doi: 10.1016/j.ahj.2019.06.012. [Epub ahead of print] PMID: 31473324

Maximal Recruitment Open Lung Ventilation in Acute Respiratory Distress Syndrome (PHARLAP): A Phase II, Multicenter, Randomized, Controlled Trial. Hodgson CL, Cooper DJ, Arabi Y, King V, Bersten A, Bihari S, Brickell K, Davies A, Fahey C, Fraser J, McGuinness S, Murray L, Parke R, Paul E, Tuxen D, Vallance S, Young M, Nichol A; PHARLAP Study Investigators and the ANZICS Clinical Trials Group. Am J Respir Crit Care Med. 2019 Jul 29. doi: 10.1164/rccm.201901-0109OC. [Epub ahead of print]  PMID: 31356105

Biomarker Predictors of Adverse Acute Kidney Injury Outcomes in Critically Ill Patients: The Dublin Acute Biomarker Group Evaluation Study. McMahon BA, Galligan M, Redahan L, Martin T, Meaney E, Cotter EJ, Murphy N, Hannon C, Doran P, Marsh B, Nichol A, Murray PT. Am J Nephrol. 2019 Jun 14:1-10. doi: 10.1159/000500231. PMID: 31203271

Impact of Early Acute Kidney Injury on Management and Outcome in Patients With Acute Respiratory Distress Syndrome: A Secondary Analysis of a Multicenter Observational Study.McNicholas BA, Rezoagli E, Pham T, Madotto F, Guiard E, Fanelli V, Bellani G, Griffin MD, Ranieri M, Laffey JG; ESICM Trials Group and the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) Investigators. Crit Care Med. 2019 Sep;47(9):1216-1225. doi: 10.1097/CCM.0000000000003832. PMID: 31162201

Advancing preparedness for clinical research during infectious disease epidemics.Gobat N, Amuasi J, Yazdanpanah Y, Sigfid L, Davies H, Byrne JP, Carson G, Butler C, Nichol A, Goossens H. ERJ Open Res. 2019 May 20;5(2). pii: 00227-2018. doi: 10.1183/23120541.00227-2018. eCollection 2019 Apr. Erratum in: ERJ Open Res. 2019 Jul 29;5(3):. PMID: 31123684

Early Sedation with Dexmedetomidine in Critically Ill Patients. Shehabi Y, Howe BD, Bellomo R, Arabi YM, Bailey M, Bass FE, Bin Kadiman S, McArthur CJ, Murray L, Reade MC, Seppelt IM, Takala J, Wise MP, Webb SA; ANZICS Clinical Trials Group and the SPICE III Investigators. N Engl J Med. 2019 Jun 27;380(26):2506-2517. doi: 10.1056/NEJMoa1904710. Epub 2019 May 19. PMID: 31112380

Prophylactic Hypothermia for Severe Traumatic Brain Injury-Reply. Cooper DJ, Nichol AD, McArthur C. JAMA. 2019 May 7;321(17):1726. doi: 10.1001/jama.2019.1538. PMID: 31063568

Fresh Red Cells for Transfusion in Critically Ill Adults: An Economic Evaluation of the Standard Issue Transfusion Versus Fresher Red-Cell Use in Intensive Care (TRANSFUSE) Clinical Trial. Irving A, Higgins A, Ady B, Bellomo R, Cooper DJ, French C, Gantner D, Harris A, Irving DO, Murray L, Nichol A, Petrie D, McQuilten ZK; Standard Issue Transfusion versus Fresher Red-Cell Use in Intensive Care (TRANSFUSE) Investigators and Australian and New Zealand Intensive Care Society Clinical Trials Group. Crit Care Med. 2019 Jul;47(7):e572-e579. doi: 10.1097/CCM.0000000000003781. PMID: 31008734

Quality of Life and 1-Year Survival in Patients With Early Septic Shock: Long-Term Follow-Up of the Australasian Resuscitation in Sepsis Evaluation Trial.

Higgins AM, Peake SL, Bellomo R, Cooper DJ, Delaney A, Harris AH, Howe BD, Nichol AD, Webb SA, Williams PJ; Australasian Resuscitation in Sepsis Evaluation (ARISE) Investigators and the ANZICS Clinical Trials Group. Crit Care Med. 2019 Jun;47(6):765-773. doi: 10.1097/CCM.0000000000003762. PMID: 30985391

Cost-Effectiveness of Erythropoietin in Traumatic Brain Injury: A Multinational Trial-Based Economic Analysis. Knott RJ, Harris A, Higgins A, Nichol A, French C, Little L, Haddad S, Presneill J, Arabi Y, Bailey M, Cooper DJ, Duranteau J, Huet O, Mak A, McArthur C, Pettilä V, Skrifvars MB, Vallance S, Varma D, Wills J, Bellomo R. J Neurotrauma. 2019 May 23. doi: 10.1089/neu.2018.6229. PMID: 30907230

Reported practice of temperature adjustment (α-stat v pH-stat) for arterial blood gases measurement among investigators from two major cardiac arrest trials. Eastwood GM, Nielsen N, Nichol AD, Skrifvars MB, French C, Bellomo R. Crit Care Resusc. 2019 Mar;21(1):69-71. PMID: 30857515

Outcomes of Patients Presenting with Mild Acute Respiratory Distress Syndrome: Insights from the LUNG SAFE Study. Pham T, Serpa Neto A, Pelosi P, Laffey JG, De Haro C, Lorente JA, Bellani G, Fan E, Brochard LJ, Pesenti A, Schultz MJ, Artigas A; LUNG SAFE Investigators* and the European Society of Intensive Care Medicine Trials Group. Anesthesiology. 2019 Feb;130(2):263-283. doi: 10.1097/ALN.0000000000002508. PMID: 30499850 

Spontaneous Breathing in Early Acute Respiratory Distress Syndrome: Insights From the Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE Study. van Haren F, Pham T, Brochard L, Bellani G, Laffey J, Dres M, Fan E, Goligher EC, Heunks L, Lynch J, Wrigge H, McAuley D; Large observational study to UNderstand the Global impact of Severe Acute respiratory Failure (LUNG SAFE) Investigators. Crit Care Med. 2019 Feb;47(2):229-238. doi: 10.1097/CCM.0000000000003519. PMID: 30379668.

 

2018

Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients With Severe Traumatic Brain Injury: The POLAR Randomized Clinical Trial.
Cooper DJ, Nichol AD, Bailey M, Bernard S, Cameron PA, Pili-Floury S, Forbes A, Gantner D, Higgins AM, Huet O, Kasza J, Murray L, Newby L, Presneill JJ, Rashford S, Rosenfeld JV, Stephenson M, Vallance S, Varma D, Webb SAR, Trapani T, McArthur C; POLAR Trial Investigators and the ANZICS Clinical Trials Group.
JAMA. 2018 Dec 4;320(21):2211-2220. doi: 10.1001/jama.2018.17075.

Priority Needs for Conducting Pandemic-Relevant Clinical Research With Children in Europe: A Consensus Study With Pediatric Clinician-Researchers.
Gal M, Gobat N, Francis NA, Hood K, Butler CC, Bielicki J, Fraaij PL, Sharland M, Jarvis J, van Rossum AMC, Heikkinen T, Martinon-Torres F, Herberg J, Watkins A, Webb SAR, Moore R, Sukumar P, Nichol A.
Pediatr Infect Dis J. 2018 Sep 25. doi: 10.1097/INF.0000000000002204. [Epub ahead of print]
PMID: 30256315

A cluster randomised, crossover, registry-embedded clinical trial of proton pump inhibitors versus histamine-2 receptor blockers for ulcer prophylaxis therapy in the intensive care unit (PEPTIC study): study protocol.
Young PJ, Bagshaw SM, Forbes A, Nichol A, Wright SE, Bellomo R, Bailey MJ, Beasley RW, Eastwood GM, Festa M, Gattas D, van Haren F, Litton E, Mouncey PR, Navarra L, Pilcher D, Mackle DM, McArthur CJ, McGuinness SP, Saxena MK, Webb S, Rowan KM; Australian and New Zealand Intensive Care Society Clinical Trials Group on behalf of the PEPTIC investigators.
Crit Care Resusc. 2018 Sep;20(3):182-189.
PMID: 30153780

 

Erythropoietin in traumatic brain injury associated acute kidney injury: A randomized controlled trial.
Skrifvars MB, Moore E, Mårtensson J, Bailey M, French C, Presneill J, Nichol A, Little L, Duranteau J, Huet O, Haddad S, Arabi Y, McArthur C, Cooper DJ, Bellomo R; EPO-TBI Investigators and the ANZICS Clinical Trials Group.
Acta Anaesthesiol Scand. 2019 Feb;63(2):200-207. doi: 10.1111/aas.13244. Epub 2018 Aug 21.
PMID: 30132785

Changes in Temperature Management of Cardiac Arrest Patients Following Publication of the Target Temperature Management Trial.
Salter R, Bailey M, Bellomo R, Eastwood G, Goodwin A, Nielsen N, Pilcher D, Nichol A, Saxena M, Shehabi Y, Young P; Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation (ANZICS-CORE).
Crit Care Med. 2018 Nov;46(11):1722-1730. doi: 10.1097/CCM.0000000000003339.
PMID: 30063490

Permissive Hypercapnia, Alveolar Recruitment and Low Airway Pressure (PHARLAP): a protocol for a phase 2 trial in patients with acute respiratory distress syndrome.
Hodgson C, Cooper DJ, Arabi Y, Bennett V, Bersten A, Brickell K, Davies A, Fahey C, Fraser J, McGuinness S, Murray L, Parke R, Tuxen D, Vallance S, Young M, Nichol AD; PHARLAP Study Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group.
Crit Care Resusc. 2018 Jun;20(2):139-149.
PMID:29852853

The undiscovered country: therapeutic targeting of carbon dioxide levels in critically ill patients.

Nichol AD.
Crit Care Resusc. 2018 Jun;20(2):81-82. No abstract available.
PMID: 29852844

 

Pathophysiology of severe traumatic brain injury.
O'leary RA, Nichol AD.
J Neurosurg Sci. 2018 Oct;62(5):542-548. doi: 10.23736/S0390-5616.18.04501-0. Epub 2018 May 22. Review.
PMID:29790727

Statistical analysis plan for the POLAR-RCT: The Prophylactic hypOthermia trial to Lessen trAumatic bRain injury-Randomised Controlled Trial.
Presneill J, Gantner D, Nichol A, McArthur C, Forbes A, Kasza J, Trapani T, Murray L, Bernard S, Cameron P, Capellier G, Huet O, Newby L, Rashford S, Rosenfeld JV, Smith T, Stephenson M, Varma D, Vallance S, Walker T, Webb S, James Cooper D; POLAR investigators and the ANZICS Clinical Trials Group.
Trials. 2018 Apr 27;19(1):259. doi: 10.1186/s13063-018-2610-y.
PMID:29703266

Effect of age of red cells for transfusion on patient outcomes: a systematic review and meta-analysis.
McQuilten ZK, French CJ, Nichol A, Higgins A, Cooper DJ.
Transfus Med Rev. 2018 Apr;32(2):77-88. doi: 10.1016/j.tmrv.2018.02.002. Epub 2018 Feb 17.

Bending the Pandemic Curve: Improving Decision-Making With Clinical Research.
Webb SA, Nichol AD.
Crit Care Med. 2018 Mar;46(3):442-446. doi: 10.1097/CCM.0000000000002912. No abstract available.
PMID: 29474325

 

 

2017

Bellani G, Laffey JG, Pham T, Madotto F, Fan E, Brochard L, Esteban A, Gattinoni L, Bumbasirevic V, Piquilloud L, van Haren F, LarssoA, McAuley DF, Bauer PR, Arabi YM, Ranieri M, Antonelli M, Rubenfeld GD, Thompson BT, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators; ESICM Trials Group.
Noninvasive Ventilation of Patients with Acute Respiratory Distress Syndrome. Insights from the LUNG SAFE Study.
Am J Respir Crit Care Med. 2017 Jan 1;195(1):67-77. doi: 10.1164/rccm.201606-1306OC
PMID: 27753501

Cosgrave D, Galligan M, Soukhin E, McMullan V, McGuinness S, Puttappa A, Conlon N, Boylan J, Hussain R, Doran P, Nichol A.
The NAPRESSIM trial: the use of low-dose, prophylactic naloxone infusion to prevent respiratory depression with intrathecally administered morphine in elective hepatobiliary surgery: a study protocol and statistical analysis plan for a randomised controlled trial.
Trials. 2017 Dec 29;18(1):633. PMID: 29284510

D James Cooper, Zoe K McQuilten, Alistair Nichol, Bridget Ady, Cécile Aubron, Michael Bailey, Rinaldo Bellomo, Dashiell Gantner, David O Irving, Kirsi-Maija Kaukonen, Colin McArthur, Lynne Murray, Ville Pettilä, Craig French 
Age of Red Cells for Transfusion and Outcomes in Critically Ill Adults
N Engl J Med. 2017 Sep 27

Eastwood GM, Nichol A, Wise MP.
Targeted therapeutic mild hypercapnia after cardiac arrest.
Crit Care. 2017 Jul 31;21(1):196. doi: 10.1186/s13054-017-1770-6. No abstract available. 
PMID: 28756765 

French CJ, Glassford NJ, Gantner D, Higgins AM, Cooper DJ, Nichol A, Skrifvars MB, Imberger G, Presneill J, Bailey M, Bellomo R.
Erythropoiesis-stimulating Agents in Critically Ill Trauma Patients: A Systematic Review and Meta-analysis.
Ann Surg. 2017 Jan;265(1):54-62.

Gantner DC, Bailey M, Presneill J, French CJ, Nichol A, Little L, Bellomo R; EPO-TBI Investigators; and the ANZICS Clinical Trials Group.
Erythropoietin to Reduce Mortality in Traumatic Brain Injury: A Post-hoc Dose-effect Analysis.
Ann Surg. 2017 Feb 1.

Gobat NH, Butler CC, Webb SAR, Nichol A; PREPARE-EARL Study Team.
Comment on Rishu et al. Time required to initiate outbreak and pandemic observational research.
J Crit Care. 2017 Aug;40:271. doi: 10.1016/j.jcrc.2017.03.019. Epub 2017 Mar 27. No abstract available. PMID:28438372

Parke RL, McGuinness S, Eastwood GM, Nichol A, Nielsen N, Dankiewicz J, Bellomo R.
Co-enrolment for the TAME and TTM-2 trials: the cerebral option.
Crit Care Resusc. 2017 Jun;19(2):99-100. 

PRISM Investigators, Rowan KM, Angus DC, Bailey M, Barnato AE, Bellomo R, Canter RR, Coats TJ, Delaney A, Gimbel E, Grieve RD, Harrison DA, Higgins AM, Howe B, Huang DT, Kellum JA, Mouncey PR, Music E, Peake SL, Pike F, Reade MC, Sadique MZ, Singer M, YealyDM.
Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis.
N Engl J Med. 2017 Jun 8;376(23):2223-2234. doi: 10.1056/NEJMoa1701380. Epub 2017 Mar 21.
PMID:28320242

Skrifvars MB, French C, Bailey M, Presneill J, Nichol A, Little L, Duranteau J, Huet O, Haddad S, Arabi Y, McArthur C, Cooper DJ, Bellom R.
J Neurotrauma.
Cause and timing of death and sub-group differential effects of erythropoietin in the EPO-TBI study.
2017 Oct 12. doi: 10.1089/neu.2017.5135. 

Skrifvars MB, Bailey M, French C, Presneill J, Nichol A, Little L, Duranteau J, Huet O, Haddad S, Arabi Y, McArthur C, Cooper DJ, Bellomo R; EPO-TBI investigators and the ANZICS Clinical Trials Group.
Erythropoietin in patients with traumatic brain injury and extracranial injury-A post hoc analysis of the erythropoietin traumatic brain injury trial.
J Trauma Acute Care Surg. 2017 Sep;83(3):449-456. 

Skrifvars MB, Bailey M, Presneill J, French C, Nichol A, Little L, Duranteau J, Huet O, Haddad S, Arabi Y, McArthur C, Cooper DJ, Bellomo R; EPO-TBI investigators and the ANZICS Clinical Trials Group.
Venous thromboembolic events in critically ill traumatic brain injury patients.
Intensive Care Med. 2017 Mar;43(3):419-428. 

 

 

2016

WHO - Guidance For Managing Ethical Issues In Infectious Disease Outbreaks
Authors - Including Professor A. Nichol, SVUH/UCD Read More...

JAMA. 2016;315(8):788-800. doi:10.1001/jama.2016.0291
Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries
Giacomo Bellani, MD, PhD1,2; John G. Laffey, MD, MA3,4; Tài Pham, MD5,6,7; et al

J Crit Care. 2016 May 26;35:126-132. doi: 10.1016/j.jcrc.2016.05.017. [Epub ahead of print]
Defining the characteristics and expectations of fluid bolus therapy: A worldwide perspective.
Glassford NJ1, Mårtensson J2, Eastwood GM3, Jones SL4, Tanaka A4, Wilkman E5, Bailey M6, Bellomo R7; GLobal OBservational Evaluations in the ICU (GLOBE-ICU) investigators.

Ann Surg. 2016 Apr 8. [Epub ahead of print]
Erythropoiesis-stimulating Agents in Critically Ill Trauma Patients: A Systematic Review and Meta-analysis.
French CJ, Glassford NJ, Gantner D, Higgins AM, Cooper DJ, Nichol A, Skrifvars MB, Imberger G, Presneill J, Bailey M, Bellomo R.

N Engl J Med. 2016 Apr 7;374(14):1384. doi: 10.1056/NEJMc1600339#SA3.
Hypothermia for Intracranial Hypertension after Traumatic Brain Injury.
Cooper DJ1, Nichol A1, Presneill J1.

JAMA. 2016 Feb 23;315(8):788-800. doi: 10.1001/jama.2016.0291.
Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries.
Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, Gattinoni L, van Haren F, Larsson A, McAuley DF, Ranieri M, Rubenfeld G, Thompson BT, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators; ESICM Trials Group.

Lancet 2015;386(10012):2499–2506 Paper
Erythropoietin in traumatic brain injury (EPO-TBI): a double-blind randomised controlled trial.
Nichol A, French C, Little L, Haddad S, Presneill J, Arabi Y, Bailey M, Cooper DJ, Duranteau J, Huet O, Mak A, McArthur C, Pettilä V, Skrifvars M, Vallance S, Varma D, Wills J, Bellomo R; EPO-TBI Investigators and the ANZICS Clinical Trials Group.

Cooper DJ, Nichol A, Hodgson C.
Craniectomy for Traumatic Intracranial Hypertension.
N Engl J Med. 2016 Dec 15;375(24):2402. No abstract available. 
PMID: 28032966

 

 

2015

Catalin I. Efrimescu, Anaesthesia Registrar Crina L. Burlacu, Consultant Anaesthetist St. Columcille's/St. Vincent's University Hospitals, Dublin, Ireland
A case report of anaesthesia complications in a patient with a low body mass index
British Journal of Anaesthesia, E-Letters, April 2015

 

2014

H. Shakeban, N. Conlon and J. Boylan
Stroke volume and systolic pressure variation for prediction of fluid responsiveness during major pancreatic surgery
British Journal of Anaesthesia 113 (5): 891–4P (2014)

Considerations in providing safe anaesthesia in a patient with mastocytosis
Crina L. Burlacu, Consultant Anaesthetist, Robert ffrench-O'Corroll, Colin Morrison St. Vincent's Hospital Group
Read More...

Kinsley Enohumah, S. Raza Mehdi, Alan J. McShane & Crina L. Burlacu
Paravertebral block as a sole technique for the anaesthetic management of a patient with myalgic encephalomyelitis undergoing breast cancer surgery (pages 164-166)
Southern African Journal of Anaesthesia and Analgesia Volume 20, Issue 3, 2014

 

2013

Zacharias, M., Mugawar, M., Herbison, G. P., Walker, R. J., Hovhannisyan, K., Sivalingam, P., & Conlon, NP. (2013).
Interventions for protecting renal function in the perioperative period.

Fröhlich, S., Murphy, N., Doolan, A., Ryan, O., & Boylan, J. (2013).
Acute respiratory distress syndrome: Underrecognition by clinicians.
Journal of critical care.

Fröhlich, S., Murphy, N., Ryan, D., & Boylan, J. (2013).
Acute respiratory distress syndrome: current concepts and future directions.
Anaesthesia and intensive care, 41(4), 463-472.

Fröhlich, S., Boylan, J., & McLoughlin, P. (2013).
Hypoxia-Induced Inflammation in the Lung: A Potential Therapeutic Target in Acute Lung Injury?.
American journal of respiratory cell and molecular biology, 48(3), 271-279.

 

 

2012

A Praeger, A Westbrook, A Nichol, R Wijemunige, A Davies, S Lyons, J Wills, Michael Bailey, Rosenfeld, DJ Cooper
THE RELEVENT STUDY: Deep venous thrombosis in patients with traumatic brain injury: a prospective observational study
Critical Care and Resusitation
Click here for Link

Deepak Kumar, Brendan O'Hare, Conard Timon, M Mukhtar, Dermot Kelly
Bilateral pneumothoraces and pulmonary oedema following tracheostomy induced by acute tracheal obstruction
BMJ Case Reports 2012; doi:10.1136/bcr-2012-006557
Click here for link

 

McDermott G, Korba E, Mata U, Jaigirdar M, Narayanan N, Boylan J, Conlon N;
Should we stop doing blind transversus abdominis plane blocks?
Br J Anaesthesia 2012; 108 (3): 499-502

Philip Johnson, Andrew Westbrook
Coagulation Measurement and Optimisation in Cardiac Surgery
Perioperative Considerations in Cardiac Surgery, ISBN: 978-953-51-0147-5
Click here for link

 

 

2011

D Gantner, A Nichol
Treatment of Severe Sepsis
Anaesthesia and Intensive Care Medicine

J Hanna, A Nichol
Acute Kidney Injury
Anaesthesia and Intensive Care Medicine

J Hanna, A Nichol
Status Epliplticus
Anaesthesia and Intensive Care Medicine

S Hew, A Nichol
Acute Severe Pancreatitis 
Anaesthesia and Intensive Care Medicine

E Moore, S Bernard, J Cooper, A Nichol
Chapter `Hypothermia: history, mechanisms, complications, indications and future directions`
Hypothermia: Prevention, Recognition and Treatment, Nova publishing

Nichol A, J Rosenfeld, DJ Cooper
Chapter: `Future perspectives for the treatment of TBI patients: decompressive craniectomy, hypothermia and erythropoietin`
Traumatic brain and spinal cord injury: Challenges and developments in research - Translating Research into Clinical Practice, Cambridge University Press

R Bellomo, M Bailey, A Nichol (on behalf of the Study of Oxygen in Critical Care Group)
Hyperoxia and Mortality after Resuscitation
Circulation 2011 IF 10.9

R Bellomo, M Bailey, GEastwood, A Nichol, D Pilcher, G Hart, M Reade, DJ Cooper, M Egi
Arterial Hyperoxia and in-Hospital Mortality after Resuscitation
Critical Care 2011 Mar 8;15(2):R90. PMID: 21385416 IF 5.0

Boylan JF, Conlon NP, Jaigirdar MJ.
Consent in emergency care research
Lancet. 2011 Jul 2;378(9785):25.

Burlacu CL, McKeating K, McShane AJ.
Remifentanil for the insertion and removal of long-term central venous access during monitored anesthesia care
J Clin Anesth. 2011 Jun;23(4):286-91
Click here for link

Carol L Hodgson, David V Tuxen, Andrew R Davies, Michael J Bailey, Alisa M Higgins, Anne E Holland, Jenny L Keating, David Pilcher, Andrew J Westbrook, David J Cooper and Alistair Nichol.
A randomised controlled trial of an open lung strategy with staircase recruitment titrated PEEP and targeted low airway pressures in patients with acute respiratory distress syndrome.
Critical Care 2011 15:R133 doi 10.11 86/cc10249 MS ID 1648151195478278

Cecile Aubron, Gillian Syres, Alistair Nichol, Michael Bailey, Jasmin Board, Geoff Magrin, Lynnette Murray, Jeffrey Presneill, Joanne Sutton, Shirley Vallance, Siouxzy Morrison, Rinaldo Bellomo, D Jamie Cooper
A pilot feasibility trial of allocation of freshest available red blood cells versus standard care in critically ill patients
Transfusion 2011 (in press) IF 3.3

C Hodgson, D Tuxen, A Davies, M Bailey, A Higgins, A Holland, J Keating, D Pilcher, A Westbrook,
D Cooper, A Nichol
A Randomised Controlled Trial of an Open Lung Strategy with Staircase Recruitment, Titrated PEEP and Targeted Low Airway Pressures in Patients with ARDS
Critical Care 2011;15(3):R133. 2011 Jun 2. PMID: 21635753 IF 5.0 

Egi M, Kim I, Nichol A, Stachowski E, French CJ, Hart GK, Hegarty C, Bailey M, Bellomo R.
Ionized calcium concentration and outcome in critical illness.
Crit Care Med 2011; 39:314 –321. PMID: 21099425 IF 6.4

Jaigirdar MJ, Ahmed S, Conlon N.
Should limited term intraoperative epidural analgesia be used in patients undergoing hepatic resection?
Anesth Analg. 2011 Apr;112(4):993-4.

Moore EM, Nichol AD, Bernard SA, Bellomo R
Therapeutic hypothermia: benefits, mechanisms and potential clinical applications in neurological, cardiac and kidney injury
Injury. 2011 Apr 8. [Epub ahead of print] PMID: 21481385 IF 2.8

E Moore, R Bellomo, AD Nichol
Erythropoietin (EPO) as a novel brain and kidney protective agent
Anaesthesia and Intensive Care 2011 May;39(3):356-72. PMID: 21675055 IF: 1.1

R. C. N. McMorrow, J. S. Windsor, M. G. Mythen, M. P. W. Grocott, and the Caudwell Xtreme Everest Research Group
A novel ambulatory closed circuit breathing system for use during exercise
Anaesthesia, 2011, 66, pages 348–353
Click here for link

AD Nichol, B Gabbe, L Higgins, P Cameron
Measuring functional and quality of life outcomes following major head injury: Common scales and checklists 
Injury 2011 Mar;42(3):281-7. PMID: 21145059 IF 2.8

A Nichol, F Toal, M Fedi, DJ Cooper
Early outcome prediction after severe traumatic brain injury: can multimodal MRI assist clinical prognostication for individual patients? 
Critical Care Resuscitation 2011 Mar;13(1):5-8.

A Nichol, L Murray, T Trapani, DJ Cooper
Hypothermia in patients with brain injury: The way forward
Lancet Neurology 2011 May;10(5):405 PMID: 21511193 IF: 18.1

The Blood Observational Study Investigators on behalf of the ANZICS- Clinical Trials Group
A Nichol is a Chief Investigator and Management Committee Member:
V Pettilä, A J Westbrook, AD Nichol, MJ Bailey, EM Wood, G Syres, LE Phillips, A Street, C French, L Murray, N Orford, JD Santamaria, R Bellomo, DJ Cooper
Age of red blood cells and mortality in the critically ill
Critical Care 2011 Apr 15;15(2):R116. PMID: 21496231 IF 5.0

AD Nichol
Permissive hypercapnia in acute respiratory distress syndrome- is now the time to get strict?
Critical Care Resuscitation 2011 Sept;13(3):142-3. PMID: 21879999

A Nichol, M Bailey, M Egi, V Pettila, C French, GK Hart, E Stachowski, M Reade, DJ Cooper R Bellomo
Dynamic Lactate Indices as Predictors of Outcome in Critically Ill Patients
Critical Care 2011 (in press) IF 5.0

R. C. N. McMorrow, R. J. Ni Mhuircheartaigh, K. A. Ahmed, A. Aslani, S.C. Ng, I. Conrick-Martin, J. J. Dowling, A. Gaffney, J. P. R. Loughrey and C. L. McCaul
Comparison of transversus abdominis plane block vs spinal morphine for pain relief after Caesarean section
British Journal of Anaesthesia 106 (5): 706–12 (2011)
Click here for link

Smith Stephen, Kelly Dermot, Mukhtar Muhammed - Royal Victoria Eye and Ear Hospital, Dublin
Emergency surgery in Haemophilia sufferers - Factors and considerations.
Click here for link

Straub Birgitt , O'Hare Brendan, Power William, Mukhtar Muhammad - Royal Victoria Eye and Ear Hospital, Dublin
A Case Report: Sub-Tenon's versus General Anaesthesia – A Direct Comparison of a New Anaesthetic Approach for Corneal Graft Surgery
Click here for link

Ville Pettila, Andrew J Westbrook, Alistair D Nichol, Michael J Bailey, Erica M Wood, Gillian Syres, Louise E Phillips, Alison Street, Craig French, Lynette Murray, Neil Orford, John D Santamaria, Rinaldo Bellomo and David J Cooper.
The Blood Observational Study Investigators and the ANZICS-Clinical Trials Group. Age of red blood cells and mortality in the critically ill.
Critical Care 2011 15:R116 doi 10.1186/cc10142

Westbrook Andrew
Abdominal Compartment Syndrome. (2011) Hospital Doctor of Ireland (Intensive Care Unit Series) 17 (7): 16-19

 

 

2010

Alistair D. Nichol, Donall F. O'Cronin, Finola Naughton, Natalie Hopkins, John Boylan, Paul McLoughlin
Hypercapnic Acidosis Reduces Oxidative Reactions in Endotoxin-induced Lung Injury
Anaesthesiology 2010; 113, 116

Breatnach C, Conlon NP, Stack M, Healy M, O'Hare BP.
A prospective crossover comparison of neurally adjusted ventilatory assist and pressure-support ventilation in a pediatric and neonatal intensive care unit population
Pediatr Crit Care Med. 2010 Jan;11(1):7-11.

O. Chukudebelu, D.S. Leonard, A. Healy, D. McCoy, D. Charles, S. Hone, M. Rafferty
The effect of gastric decompression on postoperative nausea and emesis in pediatric, tonsillectomy patients
International Journal of Pediatric Otorhinolaryngology
June 2010 (Vol. 74, Issue 6, Pages 674-676)

Higgins L, Pettila V, Nichol AD, Bellomo R, Cooper DJ.
Expensive care medicine- Economic evaluations in Intensive Care Trials
Critical Care Resuscitation 2010 Mar;12(1):62-6. PMID: 20196716

Johnson P, Frohlich S, Westbrook A.
Use of an Extracorporeal Membrane Lung Assist Device (Novalung) in H1N1 patients
Journal of Cardiac Surgery JOCS-2010-CASR-521.R2 (accepted for publication)

Moore EM, Bellomo R, Nichol AD, Harley N, MacIsaac C, Cooper DJ. 
The incidence of acute kidney injury in patients with traumatic brain injury
Renal Failure 2010; 32(9):1060-1065 PMID: 20863210 IF 0.8

E Moore, R Bellomo, A Nichol
Biomarkers of acute kidney injury in intensive care and major surgery: from the lab to clinical research to clinical practice
Minerva Anestesiologica 2010 Jun;76(6):425-40. PMID: 20473256 IF: 1.6

Narayanan N, Conlon N, Seigne P.
Acute methaemoglobinaemia secondary to intentional dapsone overdose
Ir Med J. 2010 Oct;103(9):285.

ANZIC Influenza Chief Investigators
(AD Nichol is an ANZIC Influenza Chief Investigator and Management Committee Member)
Critical care services and the H1N1 (2009) influenza epidemic in Australian and New Zealand in 2010: the impact of the second winter epidemic
Critical Care 2011 Jun 9;15(3):R143. IF 5.0

Relative hyperlactatemia and hospital mortality in critically ill patients: a retrospective multi-centre study
AD Nichol, M Egi, V Pettilä, R Bellomo, C French, G Hart, A Davies, E Stachowski, M C
Reade, M Bailey, DJ Cooper
Critical Care 2010 Feb 24;14(1):R25. PMID: 20181242 received `most accessed` article IF 5.0

Chapter: `What is the optimal method for weaning and liberation from Mechanical Ventilation?`
Nichol A, Pettilla V, Cooper DJ.
An Evidence Based Practice of Critical Care 2010

Challenging issues in randomized controlled trials
Nichol A, Bailey M, Cooper DJ.
Injury. 2010 Jul;41 Suppl 1:S20-3. PMID:20413119 IF 2.8

Lactate in cardiac surgery patients: Another case of the Cassandra complex?
A Nichol, M Bailey, R Bellomo
Critical Care 2010;14(1):R25. PMID: 20529384 IF 5.0

Hypercapnic acidosis reduces oxidative reactions in endotoxin induced lung injury 
AD Nichol, DF O`Cronin, F Naughton, N Hopkins, J Boylan, Paul McLoughlin
Anesthesiology 2010 Jul;113(1):116-25. PMID: 20526182 IF 5.4

Venous Thrombus Embolism Prophylaxis in intensive care units in Australia and New Zealand
Robertson MS, Nichol AD, Higgins AM, Bailey MJ, Presneill JJ, Cooper DJ, Webb SA, McArthur C, Macisaac CM; VTE Point Prevalence Investigators.
Critical Care Resuscitation 2010 Mar;12(1):9-15. PMID: 20196708 

Twomey C, Corrigan M, Burlacu C, Butler M, Iohom G, Shorten G.
Nitric oxide index is not a predictor of cognitive dysfunction following laparotomy
J Clin Anesth. 2010 Feb;22(1):22-8.PMID: 20206847 [PubMed - in process]

The Blood Observational Study Investigators on behalf of the ANZICS-
Clinical Trials Group (A Westbrook (chair), V Pettila (chair), A Nichol, MJ Bailey, G Syres, R Bellomo, E Wood, LE Phillips, C French, N Orford, J Santamaria, DJ Cooper).
Transfusion practice and guidelines in Australian and New Zealand intensive care units.
(2010) Intensive Care Medicine 36 (7): 1138-1146

The Blood Observational Study Investigators on behalf of the ANZICS- Clinical Trials Group
V Pettilä, A Westbrook, A Nichol, M Bailey, E Wood, G Syres, L Phillips, A Street, C French, L Murray, N Orford, J Santamaria, R Bellomo, D Cooper.
Transfusion practice and guidelines in Australian and New Zealand Intensive Care Units
Intensive Care Med. 2010 Jul;36(7):1138-46. PMID: 20440603 IF 5.2

Hypercapnia and Acidosis in Sepsis: A Double-edged Sword?
Curley G, Contreras M, Nichol AD, Higgins BD, Laffey JG.
Anesthesiology 2010 Feb;112(2):462-72. PMID: 20068449 IF 5.4

 

Abstract - ESRA 2010 Porto

P. Johnson, I. Browne
analgesia for lobour; Current practice in Republic of Ireland

A. Walsh, I. Browne
Obstetric Haemorrhage and transfusion implications

A. Walsh, I. Browne
Prospective audit of analgesia post cesarean section. Room for improvement?

 

 

2009

Alugu Tolu, McShane A.
Acute Pain Management for Clinicians
Irish Journal of Clinical Medicine, Vol. 39, Number 5, 2009

ANZIC Influenza Investigators.
S. Webb., V Pettilä., I Seppelt, R Bellomo, M Bailey, DJ. Cooper, M Cretikos, AR. Davies, SFinfer, P Harrigan, G Hart, B Howe, J. Iredell, C McArthur,., I Mitchell, S Morrison, AD Nichol, D Paterson, S Peake, B Richards, D Stephen, ATurner, M Yung)
Influenza A (H1N1) 2009: Impact on Critical Care Services during the Australian and New Zealand Winter
New England Journal of Medicine 2009 Nov 12;361(20):1991-3. PMID: 19815860 IF 50

JK. Barbetti, AD. Nichol, KR. Choate, MJ. Bailey, GA. Lee, DJ Cooper\\\\
Prospective observational study of complications with Percutaneous Dilatational Tracheostomy and Surgical Tracheostomy in 1163 Critically Ill Patients
Critical Care Resuscitation 2009 Dec;11(4):244-9. PMID: 20001871

Birnbach D J, Browne I M.
Millers Anaesthesia : Expert Consult Premium Edition. 
2009 Obstetric Anaesthesia

Breatnach C, Conlon NP, Stack M, Healy M, O'Hare BP.
A prospective crossover comparison of neurally adjusted ventilatory assist and pressure-support ventilation in a pediatric and neonatal intensive care unit population
Pediatr Crit Care Med. 2009 Jul 9. [Epub ahead of print] / in press
Click here for link

Conlon NP, Breatnach C, O’Hare BP, Mannion DW, Lyons BJ.
Health-related quality of life after prolonged pediatric intensive care unit stay
Pediatr Crit Care Med 2009 Jan;10(1):41-44.
Click here for link

Conlon NP, Breatnach C, O’Hare BP, Mannion DW, Lyons BJ.
Response to editorial: Outcome assessment-What outcome do we want?
Pediatr Crit Care Med 2009 Jan;10(1):135-6.
Click here for link

Chapter: `Lactic Acidosis`
Cooper DJ, Nichol A
TE Ohs Manual of Intensive Care Medicine, 6th Edition, 2009

Grocott M, Martin D, Levett D, McMorrow R, Windsor J, Montgomery H.
Arterial Blood Gases at 27,560ft (8400m) on Mount Everest.
New England Journal of Medicine, 2009 Jan 8;360(2):140-9
Click here for link

Johnson P, Browne I.
Analgesia for labour; Current practice in Republic of Ireland

Larkin C, Murphy F, Browne I.
Anaesthetic Management of pregnancy complicated by a symptomatic arachnoid cyst
IJOA 2009; 18:3: 291-92

AD. Nichol, F Naughton, D O Cronin, J Boylan, P McLoughlin 
Infection-induced lung injury is worsened after renal buffering of hypercapnic acidosis.
Critical Care Medicine 2009 Nov;37(11):2953-61. PMID:19773647 IF 6.4

Potential therapies to improve outcomes in traumatic brain injury: Something old (Prophylactic Hypothermia) and something new (erythropoietin)
AD Nichol, DJ Cooper ​
Injury 2009 May;40(5):471-8. 2009 Apr 15 PMID: 19371869 IF 2.8

Nichol A, O'Cronin D, Howell K, Naughton F, O'Brien S, Boylan J, O'Connor C, O'Toole D, Laffey J, McLoughlin P.
Infection-induced lung injury is worsened after renal buffering of hypercapnic acidosis
Crit Care Med 2009 Vol. 37, No. 11

V Pettilä, A Nichol, R Bellomo, DJ Cooper
Red blood cell transfusion and mortality in spontaneous subarachnoid hemorrhage
Critical Care Medicine 2009 Nov;37(11):2996-7; PMID:19851147 IF 64

Rohan D, Ahern S, Walsh K.
Defining an Anaesthetic Curriculum for Medical Undergraduates. A Delphi Study.
Med Teach 2009; 31: e1-5.

Walsh A, Browne I. Obstetric Haemorrhage and transfusion implications

Walsh A, Browne I. Prospective audit of analgesia post cesarean section. Room for improvement?

Walshe C, Jonas N, Rohan D.
Vallecular Cyst causing a difficult intubation.
Br J Anaesth 2009; 102: 565.

Weekes G, Breslin D.
Radiographic Appearance of a Post-Epidural Headache.
Irish Medical Journal. October 2009 Volume 102 Number 9.
Click here for link

Westbrook AJ, Olsen J, Bailey M, Bates J, Scully M, Salamonsen RF.
Protocol based on Thromboelastograph out-performs physician preference using laboratory coagulation tests to guide blood replacement during and after cardiac surgery.
Heart Lung and Circulation 18: 277-288

Zaidi N, Tariq M, Breslin D.
Perioperative use of antibiotics in elective surgical patients: timing of administration.
J Perioper Pract. 2009 Jul;19(7):225-7
Click here for link

 

 

2008

Burlacu CL.
Update on Local Anaesthetics: Focus on Levobupivacaine.
Therapeutics and Clinical Risk Management; 2008; 4:381-92.
Click here for link

Burlacu CL.
PCEA vs. PCA: Is this anymore the question? (Editorial).
Journal of Postgraduate Medicine 2008; 54(2): 80-81.
Click here for link

Burlacu CL, Chin C.
Effect of Paediatric Simulation Training on Candidate’s Confidence.
Pediatric Anesthesia; 2008; 18: 566-7

Burlacu CL
PCEA Vs PCA for post-thoracotomy pain : Is this any longer the question ?
J Postgrad Med 2008 April-June; 54 : 80-1

Conlon NP, Shaw AD, Grichnik KP.
Postthoracotomy paravertebral analgesia: will it replace epidural analgesia?
Anesthesiol Clin. 2008 Jun;26(2):369-80.
Click here for link

Conlon N, Grocott HP, Mackensen GB.
Neuroprotection during cardiac surgery.
Expert Rev Cardiovasc Ther. 2008 Apr;6(4):503-20.
Click here for link

Conlon NP, Bale EP, Herbison GP, McCarroll M.
Postoperative anemia and quality of life after primary hip arthroplasty in patients over 65 years old.
Anesth Analg. 2008 Apr;106(4):1056-61.
Click here for link

Conlon N, O'Brien B, Herbison GP, Marsh B.
Long-term functional outcome and performance status after intensive care unit re-admission: a prospective survey.
Br J Anaesth. 2008 Feb;100(2):219-23.
Click here for link

Crowley LJ, Buggy DJ.
Shivering and neuraxial anaesthesia: A review.
Reg Anaesth Pain Med. 2008 May-June;33(3):241 - 52

Majedi, MP, Allajade A, O'Keeffe D.
Subcutaneous Electrical Nerve Stimulation for Luterscapular Neuropathic Pain.
Pain Medicine 2008, Volume 9

McElwain J, Freir NM, Burlacu CL, Moriarty DC, Sessler DI, Buggy DJ.v The feasibility of patient-controlled paravertebral analgesia for major breast cancer surgery: a prospective, randomized, double-blind comparison of two regimens.
Anesthesia and Analgesia 2008; 107: 665-8
Click here for link

McMorrow RC, Ryan SM, Blunnie WP et al.
Use of recombinant factor VIIa in massive post-partum haemorrhage.
European Journal Anaesthesiology. 2008 April;25(4):293-8.

Moore PT, O'Hare N, Walsh KP, Ward N, Conlon N.
Objective video quality measure for application to tele-echocardiography.
Med Biol Eng Comput. 2008 Aug;46(8):807-13.
Click here for link  

Nichol AD, Westbrook AJ, Bellomo R, Cooper DJ.
Is it too early to recommend a restrictive transfusion strategy in patients with ischaemic heart disease?
Critical Care Medicine 36 (11): 3126-3127

Nichol A
The effects of Buffered Hypercapnia on the Severity of Infection Induced Lung Injury
University College Dublin Library, May, 2008

Nichol A
Chapter: `Blood transfusion in patients with coronary artery disease`
Blood and blood product usage in the ICU, JFICM Handbook, pages 71-83, 2008
Nichol AD
Restrictive red blood cell transfusion strategies in critical care: does one size really fit all?
Critical Care Resuscitation 2008 Dec;10(4):323-7. PMID: 19049485

Nichol A, Westbrook A, Bellomo R, Cooper DJ
Is it too early to recommend a restrictive transfusion strategy in critically ill patients with ischemic heart disease?
Critical Care Medicine, Nov;36(11):3126-7 2008 PMID:18941333 IF 6.4

O'Croinin DF, Nichol AD, Hopkins N, Boylan J, O'Brien S, O'Connor C, Laffey JG, McLoughlin P.
Sustained hypercapnic acidosis during pulmonary infection increases bacterial load and worsens lung injury.
Critical Care Medicine, 37(7)2128-35, 2008 PMID:18552698 IF 6.4

Ryan D, Conlon N, Phelan D, Marsh B.
The very elderly in intensive care: admission characteristics and mortality.
Crit Care Resusc. 2008 Jun;10(2):106-10.
Click here for link 

Windsor JS, McMorrow RC, Rodway GW
Oxygen on Everest: The Development of Modern Open-Circuit Systems for Mountaineers.
Aviation Space and Environmental Med 2008;79:799-804.

Zacharias M, Conlon NP, Herbison GP, Sivalingam P, Walker RJ, Hovhannisyan K.
Interventions for protecting renal function in the perioperative period.
Cochrane Database Syst Rev. 2008 Oct 2008;(4):CD003590. 
Click here for link

 

2007

Bryson GL, Macneil R, Jeyaraj LM, Rosaeg OP.
Small dose spinal bupivacaine for Cesarean delivery does not reduce hypotension but accelerates motor recovery. Can J Anaesth. 2007; 54: 531-7.
Click here for link

Burlacu CL, Frizelle HP, Moriarty DC, Buggy DJ.
Pharmacokinetics of levobupivacaine, fentanyl and clonidine following administration in thoracic paravertebral analgesia. Regional Anaesthesia and Pain Medicine 2007; 32(2):136-45
Click here for link

Burlacu CL, Carey M, Fitzpatrick C.
Anaesthesia for Caesarean section in a woman with lung cancer: a case report and review.
International Journal of Obstetric Anaesthesia. 2007; 1: 50-62
Click here for link

Burlacu CL, Buggy DJ.
Perioperative Harlequin syndrome. British Journal of Anaesthesia 2007; 98(1) 147. In reply to Co-existing Harlequin and Horner's syndromes by Majumder A and Farquhar-Smith P.

Burlacu CL, Buggy DJ.
Intraoperative Harlequin Syndrome. Anesthesia & Analgesia 2007; 104: 748-9

Conlon NP, Redmond KC, Celi LA.
Spontaneous hemothorax in a patient with neurofibromatosis type 1 and undiagnosed pheochromocytoma.
Ann Thorac Surg. 2007 Sep;84(3):1021-3.
Click here for link

Conlon NP, Sullivan RP, Herbison PG, Zacharias M, Buggy DJ.
The effect of leaving dentures in place on bag-mask ventilation at induction of general anesthesia.
Anesth Analg. 2007 Aug;105(2):370-3.
Click here for link

Conlon NP, Ryan D.
Transfusion in pediatric intensive care units
N Engl J Med. 2007 Jul 19;357(3):301.
Click here for link

Crawford MW, Rohan D, MacGowan CK, Macpherson BA, Shi-Joon Yoo.
Use of continuous positive airway pressure in anaesthetized infants.
Anesthesiology 2007; 106: 633-4.

Neuraxial anesthesia in a parturient with Leri-Weill dyschondrosteosis.
Int J Obstet Anesth. 2007 Jul;16(3):296-7

Nichol AD
High Frequency Oscillatory Ventilation in Acute Respiratory Distress Syndrome: Who rescues the rescuer?
Critical Care Medicine 35(6):1619-20, 2007 PMID:17522538 IF 6.4

Hu P, Majedi MP, Ilyinski O, AlMajadi A, O'Keeffe D.
Audit of Neuromodulation: Neuromodulation Volume 10 (2) 195-201

Magner JJ, Crowley KJ, Boylan JF.
Fatal ibrinolysis during orthotopic liver transplantation in patients receiving solvent/detergent-treated plasma (Octaplas).
Journal of Cardiothoracic & Vascular Anesthesia. 21(3):410-3, 2007 Jun.

Rohan D, Barlow R, Karsli C, Ames W.
Pediatric Renal Transplantation. A single centre study.
Eur J Anesthesiol 2007; 24:93-5.

Wolff CB, Richardson N, Kemp O, Kuttler A, McMorrow R et al.
Near infrared spectroscopy and arterial oxygen.
Advances in Experimental Medicine and Biology. 2007;599:183-9.

 

2006

Burlacu CL, Gaskin P, Fernandes A, Carey M, Briggs L.
A comparison of the insertion characteristics of the laryngeal
tube and the laryngeal mask airway: a study of the ED50 propofol requirements.
Anaesthesia 2006, 61(3); 229-3

Burlacu CL, Frizelle HP, Moriarty DC, Buggy DJ.
Fentanyl and clonidine as adjunctive analgesics with levobupivacaine in paravertebral analgesia for breast surgery. Anaesthesia 2006; 61: 932-7

Crawford MW, Rohan D, MacGowan CK, Macpherson BA, Shi-Joon Yoo.
Effect of Propofol and CPAP on airway size and configuration in infants.
Anesthesiology 2006; 105:45-50.

Finniss DA, Murphy PM, Brooker C, Nicholas MK & Cousins MJ (2006).
Complex Regional Pain Syndrome in Children and Adolescents.
European Journal of Pain. (Jan 23 E-pub ahead of print)

Kieran SM. Cahill RA. Browne I. Sheehan SJ. Mehigan D. Barry MC.
The effect of perioperative beta-blockade on the pulmonary function of patients undergoing major arterial surgery. European Journal of Vascular & Endovascular Surgery 2006; 32: 305-8
Click here for link

McMorrow RC, Mythen MG.
Pulse Oximetery.
Current Opinion in Critical Care. 2006 Jun;12(3):269-71

Murphy PM, Skouvaklis DE, Amadeo RA, Haberman C, Brasier DA, Cousins MJ (2006).
Intrathecal catheter granuloma associated with isolated baclofen infusion.
Anesth Analg. 102:848-852.

Murphy, Paul M (2006)
Interventional techniques in Chronic Pain Management (Part 1- Intrathecal Analgesic Chemotherapy in Chronic and Cancer Pain). Pain Wise, 5(1); 23-27.

Murphy Paul M (2006)
Interventional techniques in Chronic Pain Management (Part 2 – Stimulation Based Analgesia in Chronic Pain).
Pain Wise, 5(3).

Murphy Paul M (2006).
Acute Pain Mechanisms.
In “Encyclopaedic Reference of Pain”, RF Schmidt and WD Willis eds. Springer-Verlag, New York Press.

Murphy Paul M (2006).
Somatic Pain.
In “Encyclopaedic Reference of Pain”, RF Schmidt and WD Willis eds. Springer-Verlag, New York Press.

Murphy Paul M (2006).
Rest and Movement Pain.
In “Encyclopaedic Reference of Pain”, RF Schmidt and WD Willis eds. Springer-Verlag, New York Press.

Murphy Paul M (2006).
Appropriate Management of Postoperative Pain.
In “Encyclopaedic Reference of Pain”, RF Schmidt and WD Willis eds. Springer-Verlag, New York Press.

Murphy Paul M (2006).
Visceral Pain.
In “Encyclopaedic Reference of Pain”, RF Schmidt and WD Willis eds.Springer-Verlag, New York Press.

Rohan D, Dwyer R, Costello J, Phelan D.
Audit of Mobile Intensive Care Ambulance Service.
Ir Med J 2006; 99; 76-78.

 

2005

Awad IT, Dwyer R, Rohan D, Fanning R, Keane E, Counihan A, Cunninghan P.
Brain death and organ donation: An audit in the Irish National Transplantation and Neurosurgical Centre.
Ir Med J 2004; 97: 77-79.


Browne IM, Birnbach DJ, Stein DJ, O’Gorman DA, Kuroda M.
A comparison of Espocan and Tuohy needles for the combined spinal-epidural technique for labor analgesia. 
Anesth Analg. 2005 Aug;101(2):535-40
Click here for link

Browne I. Brady I. Hannon V. McKeating K.
Anaesthesia for pheochromocytoma and sickle cell disease in pregnancy.
International Journal of Obstetric Anesthesia 2005; 14: 66-9
Click here for link

Burlacu CL, Healy DG, Twomey C, Tierney A, Moriarty DC, Veerasingam D, Buggy DJ: Continuous gastric decompression for postoperative nausea and vomiting after coronary revascularization surgery.
Anesthesia and Analgesia 2005; 100 (2); 321-26

Burlacu CL and Buggy DJ.
Co-existing Harlequin and Horner syndromes after high thoracic paravertebral anaesthesia.
British Journal of Anaesthesia 2005; 95(6): 822-4

Crawford MW, Rohan D.
The Upper Airway in Weaver Syndrome.
Paediatr Anaesth 2005; 15: 893-6.


Crowley LJ & Cunningham AJ. (Article analysis of Marval PD et al.)
The Effects of Propfol or Sevoflurane on the Estimated Cerebral Perfusion Pressure and Zero Flow Pressure.
Survey of Anesthesiology 2005 Dec;49(6):309

Crowley LJ & Cunningham AJ (Article analysis of Pasternak et al.)
Effect of Single-Dose Dexamethasone on Blood Glucose Concentration in Patients Undergoing Craniotomy.
Survey of Anesthesiology 2005 Dec;49(6):312.

Harney D. Magner JJ. O'Keeffe D.
Complex regional pain syndrome: the case for spinal cord stimulation.
Injury 2005; 36: 357-62
Click here for link

Healy, Mel
Telemedicine in Ireland: Policies and Applications
2005
Click here for link

McCaul CL. Harney D. Ryan M. Moran C. Kavanagh BP. Boylan JF.
Airway management in the lateral position: a randomized controlled trial.
Anesthesia & Analgesia 2005; 101:1221-5
Click here for link

Murphy PM & Cousins MJ (2005).
Neural Blockade and Neuromodulation in Persistent Pain. The Paths of Pain 1975-2005.
Merskey H, Loeser JD, Dubner R eds. IASP Press

O'Croinin DF. Hopkins NO. Moore MM. Boylan JF. McLoughlin P. Laffey JG.
Hypercapnic acidosis does not modulate the severity of bacterial pneumonia-induced lung injury.
Critical Care Medicine 2005; 33: 2606-12
Click here for link

Pressman A, Doumit G, Rosaeg OP, Bell M.
A double-blind randomised controlled trial showing the analgesic and anaesthetic properties of lidocaine E to be equivalent to those of ropivacaine in carpal tunnel release surgery.
Can J Plastic Surg 2005;4:173-6
Click here for link

Rohan D, Buggy DJ, Crowley S, Lin F, Gallagher H, Moriarty DC.
Increased Incidence of Postoperative Cognitive Dysfunction 24 hrs after Minor Surgery in the Elderly.
Can J Anesth 2005; 52:137-142.

 

 

2004

Awad IT, Dwyer R, Rohan D, Fanning R, Keane E, Counihan A, Cunninghan P.
Brain death and organ donation: An audit in the Irish National Transplantation and Neurosurgical Centre.
Ir Med J 2004; 97: 77-79.

Bowers AJ, Boylan JF.
Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors.
Gene. 328:135-42, 2004 Mar 17.

Breen P. Hannon V.
Locked-in syndrome: a catastrophic complication after surgery.
British Journal of Anaesthesia 2004 92:286-8
Click here for link

Crowe S, Westbrook A, Bourke M, Lyons B, Russell J.
Impossible laryngeal intubation in an infant with Fraser Syndrome.
Paediatric Anaesthesia 14 (3): 276-278

Laffey JG. Honan DM. Hopkins N. Boylan JF. McLoughlin P.
Hypercapnic acidosis attenuates endotoxin-induced acute lung injury.
American Journal of Respiratory & Critical Care Medicine 2004; 169: 46-56
Click here for link

Lane A, Westbrook A, Grady D, O'Connor R, Counihan TJ, Marsh B, Laffey JG.
Maternal brain death: medical, ethical and legal issues.
Intensive Care Medicine 30 (7): 1484-1486

Harney D. Victory R.
Traumatic syrinx after implantation of an intrathecal catheter.
Regional Anesthesia & Pain Medicine 2004; 29: 606-9
Click here for link

Murphy, PM. & MacSullivan, R (2004).
Spinal Cord Stimulation for Refractory Angina Pectoris: A Shocking Experience.
Neuromodulation. 7: 246-248.

Murphy PM, Murphy KJ, Moriarty D, Regan CE (2004).
Serotonergic inputs modulate memory consolidation at discrete time points post memory consolidation in the rat model.
Anesth Analg. 98:S1-S284.

Niazi A. Leonard IE. O'Kelly B.
Prolonged neuromuscular blockade as a result of malnutrition-induced pseudocholinesterase deficiency.
Journal of Clinical Anesthesia 2004; 16: 40-2
Click here for link

 

 

 2003

Bowers AJ, Scully S, Boylan JF.
SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia.
Oncogene. 22(18):2823-35, 2003 May 8.

Browne IM. Birnbach DJ.
Neurocysticercosis: a new differential in the diagnosis of postdural puncture headache.
Anesthesia & Analgesia 2003; 97: 580-2
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Browne I, Byrne H, Briggs L.
Sickle cell disease in pregnancy. Eur J Anaesthesiol. 2003 Jan;20(1):75-6.
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Campbell N, Rosaeg OP, Chan K:
Anaesthetic management of a parturient with pulmonary stenosis and aortic regurgitation for Caesarean section.
Br J Anaesth 2003;90:241-3
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Crowe S. Collins L.
Suxamethonium and donepezil: a cause of prolonged paralysis.
Anesthesiology 2003; 98:  574 -5

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Laffey JG. Tobin E. Boylan JF. McShane AJ.
Assessment of a simple artificial neural network for predicting residual neuromuscular block.
British Journal of Anaesthesia 2003; 90: 48-52

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Loughrey JP. Laffey JG. Moore BJ. Lynch F. Boylan JF. McLoughlin P.
Interleukin-1 beta rapidly inhibits aortic endothelium-dependent relaxation by a DNA transcription-dependent mechanism.
Critical Care Medicine 2003; 31: 910-5
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McMorrow RCN, Mirakhur RK.
A new mirrored laryngoscope for difficult intubation.
Anaesthesia. 2003 October;58(10):998-1002.

McMorrow R.
First ascent PK6175.
American Alpine Journal 2003; 370-71

Murphy PM, Stack D, Kinirons B, Laffey JG (2003).
Optimizing the dose of intrathecal morphine in older patients undergoing hip arthroplasty.

Anesth Analg. 97:1709-15.

Westbrook A, Buggy D.
Anaesthesia for breast surgery
British Journal of Anaesthesia CEPD Reviews 8 (5): 151-154

2002

Honan DM. Breen PJ. Boylan JF. McDonald NJ. Egan TD.
Decrease in bispectral index preceding intraoperative hemodynamic crisis: evidence of acute alteration of propofol pharmacokinetics. Anesthesiology 2002; 97:1303-5

McCaul C. Tobin E. Boylan JF. McShane AJ.
Atracurium is associated with postoperative residual curarization.
British Journal of Anaesthesia 2002; 89: 766-9

Laffey JG. Boylan JF. Cheng D.
The systemic inflammatory response to cardiac surgery: implications for the anesthesiologist.
Anesthesiology 2002; 97: 215-52

Laffey JG. Boylan JF.
Cyclizine and droperidol have comparable efficacy and side effects during patient-controlled analgesia.
Irish Journal of Medical Science 2002; 171: 141-4

Laffey JG. Kavanagh BP.
Hypocapnia.
New England Journal of Medicine 2002: 347: 44-53

Crowe S.Anaesthetic management of the elderly surgical patient with cognitive impairment.
Hospital Medicine 2002; 63: 445.

Duncan MA. McNicholas W. O'Keeffe D. O'Reilly M.
Periosteal infusion of bupivacaine/morphine post sternal fracture: a new analgesic technique.
Regional Anesthesia & Pain Medicine 2002; 27: 316-8

Crowe S.
Obtaining consent in the elderly patient.
Hospital Medicine 2002; 63: 61

Campbell N, Rosaeg OP:
Anaesthetic management of a parturient with Ehlers-Danlos IV syndrome.
Can J Anaesth 2002;49:493-6

Rosaeg OP, Campbell N, Crossan MJ:
Epidural analgesia does not prolong third stage of labor.
Can J Anaesth 2002;49:4902

Rohan D, Cunningham AJ.
Randomised Controlled Trial of Surgery for Temporal-Lobe Epilepsy.
Survey of Anesthesiology 2002; 46:142-143.

Rohan D, Cunningham AJ.
Endocrine Response to Surgical Stress in Three Patients Over 100 years.
Survey of Anesthesiology 2002; 46:19-20.

Fraser WD, Cayer M, Soeder B, Turcot L, Marcoux for the PEOPLE (Pushing Early or Pushing Late With Epidural) Study Group (incl. Rosaeg OP):
Risk Factors for Difficult Delivery in Nulliparas With Epidural Analgesia in Second Stage of Labor.
Obstet Gynecol 2002;99:409-18

Campbell N, Bryson G, Rosaeg OP, Crossan M-L, Bragg PR, Bell M:
Does intravenous dexamethasone prevent nausea and vomiting after reduction mammoplasty?
Can J Plast Surg 2002;10:206-9

Wilson CM, Bakewell SE, Miller MR, Hart ND, McMorrow RC et al.
Increased resting bronchial tone in normal subjects acclimatized to altitude.
Thorax. 2002 May;57(5):400-4

Yue EW, Higley CA, DiMeo SV, Carini DJ, Nugiel DA, Benware C, Benfield PA, Burton CR, Cox S, Grafstrom RH, Sharp DM, Sisk LM, Boylan JF, Muckelbaeur JK, Smallwood AM, Chen H, Chang CH, Seitz SP, Traino GL.
Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 3. Structure activity relationships at C3(1,2).
Journal of Medicinal Chemistry. 45(24):5233-48, 2002 Nov 21.

 Prior 5 Years (2001-1997)

Browne IM, Birnbach DJ
A pregnant woman with previous anaphylactic reaction to local anesthetics: a case report
Am J Obstet Gynecol. 2001 Nov;185(5):1253-4

Birnbach DJ, Browne IM, Kim A, Stein DJ, Thys DM. 
Identification of polysubstance abuse in the parturient.
Br J Anaesth. 2001 Sep;87(3):488-90

Browne IM, Birnbach DJ.  
Unmasked mischief.  
Anesth Analg. 2001 Jan;92(1):279-81

Griffin MJ. Breen PM. O'Connor JJ. Hannon V.
Desflurane, compared to halothane, augments phenylephrine-induced contraction in isolated rat aorta smooth muscle.  
Canadian Journal of Anaesthesia 2001 48:361-8

Fagan C. Frizelle HP. Laffey J. Hannon V. Carey M.
The effects of intracuff lidocaine on endotracheal-tube-induced emergence phenomena after general anesthesia. Anesthesia & Analgesia 2000; 91:201-5

Ryan M. Hamilton V. Bowen M. McKenna P.
The role of a high-dependency unit in a regional obstetric hospital.
Anaesthesia 2000; 55: 1155-8

Laffey JG. Coleman M. Boylan JF.
Patients' knowledge of perioperative care. 
Irish Journal of Medical Science 2000; 169: 113-8

Sielecki TM, Boylan JF, Benfield PA, Trainor GL.
Cyclin-dependent kinase inhibitors: useful targets in cell cycle regulation.
Journal of Medicinal Chemistry. 43(1):1-18, 2000 Jan 13.

Boylan JF, Sharp DM, Leffet L, Bowers A, Pan W.
Analysis of site-specific phosphorylation of the retinoblastoma protein during cell cycle progression.
Experimental Cell Research. 248(1):110-4, 1999 Apr 10.

Laffey JG. Murphy D. Regan J. O'Keeffe D.
Efficacy of spinal cord stimulation for neuropathic pain following idiopathic acute transverse myelitis: a case report. Clinical Neurology & Neurosurgery 1999; 101: 125-7

McCrory CR. McShane AJ.
Gastroesophageal reflux during spontaneous respiration with the laryngeal mask airway.
Canadian Journal of Anaesthesia 1999; 46: 268-70

Doyle MT. Twomey CF. Owens TM. McShane AJ.
Gastroesophageal reflux and tracheal contamination during laparoscopic cholecystectomy and diagnostic gynecological laparoscopy.
Anesthesia & Analgesia 1998; 86:624-8/

Boylan JF, Katz J, Kavanagh BP, Klinck JR, Cheng DC, DeMajo WC, Walker PM, Johnston KW, Sandler AN.
Epidural bupivacaine-morphine analgesia versus patient-controlled analgesia following abdominal aortic surgery: analgesic, respitory, and myocardial effects.
Anesthesiology. 89(3):585-93, 1998 Sept

Duggan M, Browne I, Flynn C.
Adrenal failure in the critically ill.
Br J Anaesth. 1998 Sep;81(3):468-70

Griffin MJ. Brennan L. McShane AJ.
Preoperative education and outcome of patient controlled analgesia.
Canadian Journal of Anaesthesia 1998; 45: 943-8

Laffey J. Murphy D. Regan J. O'Keeffe D.
Cost-benefit analysis of spinal cord stimulation for intractable angina pectoris: a win-win scenario?
Hospital Medicine 1998; 59: 820-1

Laffey JG. Carroll M. Donnelly N. Boylan JF.
Instructions for ambulatory surgery--patient comprehension and compliance.
Irish Journal of Medical Science 1998; 167: 160-3

Lydon AM. Boylan JF.
Reversibility of parkinsonism-induced acute upper airway obstruction by benztropine therapy.
Anesthesia & Analgesia 1998; 87: 975-6

McCrory C. Crowley K.
Is repeat laparotomy of value in patients with suspected intra-abdominal sepsis in the intensive care unit?
Irish Journal of Medical Science 1997; 166: 88-91

Dempsey E. Diamond D. Smyth MR. Malone MA. Rabenstein K. McShane A.
In vitro optimisation of a microdialysis system with potential for on-line monitoring of lactate and glucose in biological samples. Analyst 1997; 122: 185-9

Freaney R. McShane A. Keaveny TV. M. McKenna M. Rabenstein K.
Novel instrumentation for real-time monitoring using miniaturized flow systems with integrated biosensors.
Annals of Clinical Biochemistry 1997; 34: 291-302

Monteith K, Rosaeg OP:
Epidural anaesthesia for transurethral resection of the prostate in a patient with carcinoid syndrome.
Can J Anaesth 1990;37:349-52.

Rosaeg OP, Suderman V, Yarnell RW:
Early respiratory depression during Caesarean section following epidural meperidine.
Can J Anaesth 1992;39:71-4.

Rosaeg OP, Kitts JB, Loren G, Byford L:
Intravenous patient-controlled fentanyl analgesia in a thrombocytopenic parturient.
Can J Anaesth 1992;39:277-81.

Rosaeg OP, Yarnell RW, Lindsay MP:
The obstetrical anaesthesia assessment clinic: A review of six years experience.
Can J Anaesth 1993:40:346-56.

Rosaeg OP, Lindsay MP:Epidural opioid analgesia after Caesarean section: A comparison of patient-controlled meperidine and single bolus injection of morphine.
Can J Anaesth 1994;41:1063-8

Zamora JE, Rosaeg OP, Lindsay PM, Crossan ML:
Haemodynamic consequences and uterine contractions following 0.5 or 1.0 liter crystalloid infusion before obstetric epidural analgesia.
Can J Anaesth 1996;43:347-52

Rosaeg OP, Morrison S, Mac Leod JP:
Anaesthetic management of labour and delivery in the parturient and mitochondrial myopathy.
Can J Anaesth 1996;43:403-7.

Rosaeg OP, Lui ACP, Cicutti, Bragg PR, Crossan ML, Krepski B:
Peri-operative multi-modal analgesia for Caesarean section: analgesia and fitness for hospital discharge.
Can J Anaesth 1997;44:803-9

Dennehy KC, Rosaeg OP:
Insertion of intrathecal catheter during labour reduces the risk of post-dural puncture headache.
Can J Anaesth 1998;45:42-5

Rosaeg OP, Cicutti NJ, Labow RS:
The Effect of Oxytocin on the Contractile Force of Human Atrial Trabeculae.
Anaesth Analg 1998;86:40-44

Dennehy KC, Rosaeg OP, Cicutti NJ, Krepski B, Sylvain JP:
Oxytocin injection after Caesarean delivery: intravenous or intramyometrial?
Can J Anaesth 1998:45:635-9

Rosaeg OP, Bell M, Cicutti NJ, Dennehy KC, Lui ACP, Krepski B:
Pre-incision Infiltration with Lidocaine Reduces Pain and Opioid Consumption after Reduction Mammoplasty.
Reg Anaesth Pain Med 1998:23;575-9

Cicutti NJ, Smyth CE, Rosaeg OP, Wilkinson M:
Oxytocin receptor binding in rat and human heart.
Can J Cardiol 1999;15:1267-73

Hooper J, Rosaeg OP, Krepski B, Johnson DH:
Tourniquet inflation during arthroscopic knee ligament surgery does not increase post-operative pain.
Can J Anaesth 1999;46:925-9

Renehan EM, Peterson RA, Penning JP, Rosaeg OP, Chow D:
Visualization of a looped and knotted epidural catheter with a guidewire.
Can J Anaesth 2000;47;329-33

Fraser WD, Marcoux S, Krauss I, Douglas J, Goulet C, Boulvain M
PEOPLE (Pushing Early or Pushing Late with Epidural) Study Group (incl. Rosaeg OP): Multicenter, randomised, controlled trial of delayed pushing for nulliparous women in the second stage of labor with continuous epidural analgesia.
Am J Obstet Gynecol 2000;182:1165-72

Rosaeg OP, Krepski B, Cicutti NJ, Dennehy KC, Lui ACP, Johnson DH:
Multi-modal pre-emptive analgesia for arthroscopic knee ligament repair.
Reg Anesth Pain Med 2001;26:125-30

Westbrook A, Cunningham AJ.
Graded Hypercapnia and Cerebral Autoregulation during Sevoflurane or Propofol Anaesthesia. Neurosurgical Anesthesia. (2001)
Survey of Anesthesiology 45 (6): 343-344

 

Books

I. Browne, D. J.Birnbach. Obstetric Anaesthesia. Chapter in Ronald D. Miller 6th Edition.Anaesthesia. 2003